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CP Test 4 > B4-068 Pyogenic Model > Flashcards

B4-068 Pyogenic Model Flashcards

1
Q

responsible for 80% of pus forming infections

A

S. aureus

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2
Q

mixture of living and dead neutrophils, bacteria, and cellular debris

A

pus

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3
Q

pus usually forms in an area of […] infection

A

persistent

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4
Q

circumscribed collection of pus associated with infection is called an

A

abscess

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5
Q

abscesses are relatively inaccessible to

2

A

antibiodies and antibiotics

need to be drained

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6
Q

TLR activates

A

macrophages

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7
Q

gram +
grapelike clusters

A

S. aureus

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8
Q

patient populations most likely to be colonized with S. aureus

3

A
  • healthcare workers
  • diabetics
  • dialysis patients
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9
Q

S. aureus clings to nasal epithelial ligands via

2

A

clf-B
IsdA

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10
Q

main site of colonization with S aureus

A

anterior nares

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11
Q

tender pustule involving hair folllicle

A

folliculits

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12
Q

small abscess that exudes purulent material from a single opening

A

furuncle

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13
Q

aggregate of furuncles with several openings

A

carbuncle

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14
Q

unilateral warmth, erythema and tenderness of the joint

A

septic arthritis

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15
Q

high fever, peripheral emboli

A

endocarditis

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16
Q

risk factors for endocarditis

5

A
  • prosthetic heart valves
  • cardiac abnormalities
  • IV drug use
  • IV catheter
  • bacteremia
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17
Q

can cause early infection in cystic fibrosis

A

S aureus

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18
Q

catheter associated infections are usually associated with

A

S. epidermidis

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19
Q

UTIs in sexually active young women are often due to

A

S. saprophyticus

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20
Q

the capsule of S. aureus helps to resist

A

phagocytosis

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21
Q

binds to the heavy chain of antibody, can inhibit opsonization

A

protein A

S. aureus

22
Q

S. aureus can activate the classical complement pathway via

23
Q

binds fibrinogen and causes production of fibrin

A

coagulase

S. aureus

24
Q

breaks down fibrin and blood clots

A

staphylokinase

S. aureus

25
Q
  • exotoxin
  • causes leukocyte destruction and necrosis in skin and lungs
A

Panton-Valentin leukocidin (PVL)

S. aureus (less than 5% of strains)

26
Q
  • result in scalded skin syndrome
  • fever, erythema, blisters
  • positive Nikolsky’s sign

2

A

ETA, ETB

exfoliatin toxins

27
Q
  • localized scalded skin syndrome
  • primarily in infants and young children
  • culture positive
  • highly communicable
  • Nikosky’s negative
A

bullous impetigo

28
Q

enterotoxins A-E and G-I are resposible for

A

food poisoning

29
Q

bind to MHC class II and interact with beta chain causing non-specific activation

A

superantigens

enterotoxins A-E and G-I

30
Q

often localized to the gut but can be fatal if systemic

A

enterotoxins

31
Q

associated with stains that produce TSST-1

A

toxic shock syndrome

also enterotoxin B and C

32
Q

fever
diffuse macular rash (sunburn)
hypotension
with systemic involvement

A

toxic shock syndrome

33
Q

[…] patients are much more susceptible to serious infections with S aureus

A

neutropenic

34
Q

produced by macrophages to recruit neutrophils

35
Q

IgG binds to antigens on S. aureus and attach to phagocyte via

A

FcyR

type II hypersensitivity

36
Q

S. aureus activates what two complement pathways?

A
  1. classical -via antibody binding
  2. alternative via teichoic acid
37
Q

C3b binds to bacteria and is broken down by Factor I into

38
Q

iC3b binds to CR3 and CR4 allowing for

A

phagocytosis

39
Q

recognition of S. aureus by […] on macrophages and dendritic cells is the most important activator of the innate system

40
Q

women who experience TSS have lower antibodies against

A

TSST-1

possible vaccination development

41
Q

most common cause of abscesses in humans

42
Q
  • gram positive
  • high temperature tolerant
  • haloduric
  • beta hemolytic
  • yellow color on mannitol salt
43
Q

most usual source of staph enterotoxin food poisoning

A

food preparer has S. aureus on hands

44
Q
  • Gram positive
  • catalase positive
  • coagulase positive
  • cocci
45
Q

bacterial endocarditis in IV drug users is most commonly caused by

2

A

Staph or strep

46
Q

Protein A binds to human IgG and activates

A

classical complement pathway

47
Q

Protein A can bind to the […] chain of Ig

48
Q

what makes protein A a super antigen?

A
  • binds to H chain of Ig
  • on B cells this causes a nonspecific activation of that B cell
49
Q

activates plasminogen to form plasmin

A

staphylokinase

50
Q

causes bullae, peeling and positive nikolsky sign

A

staphylococcal exfoliatin

51
Q

which aspect of the immune system is most crucial for protection against S. aureus?

A

opsonization

52
Q

plays little role in destroying gram positive organisms

CP Test 4 (15 decks)

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