B4-048 CBCL Congenital Heart Defects Flashcards
if the abnormal O2 is first observed in the right ventricle, what is the defect?
VSD
if the abnormal O2 is first observed in the right atrium, where is the defect?
ASD
if the abnormal O2 is first observed in the pulmonary artery, what is the defect?
ductus arteriosus
in the absence of a cardiac shunt, cardiac output is equal to
pulmonary blood flow
in the presence of a cardiac shunt, the magnitude of the shunt is equal to
the difference between CO and pulmonary blood flow
calculation for cardiac output
septum between right and left atrium doesn’t close after birth
ASD
90% of ASD cases are due to a defect in
ostium secundum
comonly associated with fetal alcohol syndrome
4
- ASD
- VSD
- PDA
- TOF
10% of ASD is due to a defect in
also associated with 25% of down syndrome cases
ostium primum
acyanotic
left to right shunt
what type of shunt is ASD?
left to right
increased O2 sat in
* right atrium
* right ventricle
* pulmonary artery
ASD
splitting S2 due to delayed pulmonic valve closure
may also have systolic murmur
ASD
- embolism starts in right side but cross to left side of heart via defect
- can enter systemic circulation and cause stroke
paradoxical embolism
treatment: ASD
specify child vs. adult
- child: monitor, may close on own
- adult: surgery, patch opening
infant cases appear after the aortic arch but before the patent ductus arteriosus
coarctation of the aorta
- lower extremity cyanosis, weak pulses
- hypertension in upper extremities
coarctation of the aorta
increased risk of HF, cerebral hemorrhage, aortic rupture, and endocarditis
coarctation of the aorta
becomes ligamentum arteriosum
ductus arteriosus
keeps ductus arteriosus open
prostaglandin E2
associated with congenital rubella syndrome
3
- PDA
- ASD
- VSD
what kind of shunt is PDA?
left to right
continous, machine like murmur
PDA
uncorrected left to right shunt increases the pulmonary blood flow causing pulmonary arterial hypertension
eisenmenger syndrome
causes late cyanosis, clubbing, and polycythemia
associated with L to R shunt
eisenmenger syndrome
closes PDA, and inhibits PGE2
indomethacin
four abnormalities of TOF
- pulmonary stenosis
- RVH
- overriding aorta
- VSD
PROVe
boot shaped heart on CXR
TOF
caused by anterosuperior displacement of the infundibular septum
TOF
what kind of shunt is TOF?
right to left
most common cause of cyanotic CHD
TOF
associated with chr 22q11
DiGeorge
TOF
why does squatting (knee chest position) reduce cyanosis?
- kinks femoral artery
- increases TPR
- increases pressure in LV
- Left > Right
- shunt temporarily reverses
treat tet spell