B4-038 Interpreting Arterial Blood Gases Flashcards
a change in the ratio of PCO2/HCO3 predicts the change in
pH
normal acid base values
pH
PCO2
HCO3
pH: 7.4
PCO2: 40
HCO3: 24
decrease in blood pH below normal range
acidemia
elevation in the blood pH above normal range
alkalemia
process that increases [H+] by increasing PCO2 or by reducing [HCO3-]
acidosis
process that reduces [H+] by reducing PCO2 or by increasing [HCO3-]
alkalosis
in a simple disorder, both PCO2 and HCO3 should move
in the same direction
will compensation return the pH to normal?
no
just trend it the right way
primary disturbance of blood [HCO3-] bicarbonate concentration
metabolic
2 types of metabolic acidosis
- anion gap
- non anion gap (hyperchloremic)
changes in ventilation are mediated by chemoreceptors in the […] and […]
carotid
lower brainstem
- [HCO3-] retention
- [HCO3-] is produced more than it is excreted
metabolic alkalosis
- nasogastric suction, vomiting
- diuretic therapy
- hyperaldosteronism (Addison’s)
- Cushing
- Exogenous steroids
- Licorice injestion
- Alkali injestion
possible causes of…
metabolic alkalosis
[HCO3-] depletion
metabolic acidosis
[HCO3-] used up as buffer for acid
anion gap acidosis
[HCO3-] loss through urine or bowel
non-anion gap acidosis
- methanol
- uremia
- DKA
- paraaldehyde
- INH/iron
- lactic adiosis-sepsis
- ethylene glycol
- salicylates/starvation
can cause…
anion gap metabolic acidosis
- hyperailmentation
- acetazolamide
- renal tubular acidosis
- diarrhea
- ureteroenteric fistula
- pancreticoduodenal fistula
can cause…
non-anion gap metabolic acidosis
equation used for metabolic acidosis when trying to assess if respiratory compensation is adequate
winter’s formula
expected pCO2= (1.5x[HCO3]) +8 +/-2