B4-055 Hypoxia Flashcards
some inefficiency of gas exchange in a normal healthy lung is due to
2
- heterogeneity of VA/Q distribution
- small veno-arterial shunt
units with a VA/Q higher than ideal have a higher […] and lower […]
higher PO2
lower CO2
units with a lower VA/Q than ideal have a lower […] and a higher […]
lower PO2
higher PCO2
under normal conditions, the V/Q ratio of the lung is
around 1
ventilation per unit volume is greatest at the […] of the lung
base
progressively smaller toward apex
perfusion is greatest at the […] of the lung
base
changes in VA/Q are lowest at the […] of the lung and increase toward the […]
base
apex
at the top of the lung
VA/Q:
PCO2:
PO2:
VA/Q: high
PCO2: low
PO2: high
at the bottom of the lung
VA/Q:
PCO2:
PO2:
VA/Q: low
PCO2: increased
PO2: decreased
alveolar ventilation will be […] in areas of low compliance
low
alveolar ventilation will be […] in areas of high compliance
high
alveolar ventilation will be […] in areas of low resistance
high
alveolar ventilation will be […] in areas of high resistance
low
for any given PaCO2, the PECO2 will be
lower
due to volume from dead space
the PECO is diluted about 1/3 compared to
PaCO2
normal VD/VT
.25-.35
when VD/VT > 0.6, patients are
ventilated
cannot maintain ventilation
low PaO2
without much increase in CO2
increased dead space
VD/VT > 0.3
increased dead space
shunt unit produce a […] in arterial PO2
large decrease
venous blood mixed with arterial blood, mixing PO2
does increased PIO2 or hyperventiliation increase PaO2 significantly?
no
shunt
shunt units produce a […] in PaCO2
small increase