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CP Test 3 > B4-056 Restrictive Pulmonary Disease > Flashcards

B4-056 Restrictive Pulmonary Disease Flashcards

1
Q
  • disorders involving inflammation and fibrosis of the lung parenchyma, particularly the interstitium
  • causes reduced diffusion capacity
A

interstitial lung disease

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2
Q

space between the epithelial and endothelial basement membranes in the alveolar wall

A

interstitium

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3
Q

fibrosing interstitial lung diseases

just the 3 she said we’re responsible for

A
  • idiopathic pulmonary fibrosis
  • non-specific interstitial pneumonia
  • pneumoconiosis
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4
Q

insidious onset of dyspnea on exertion
dry cough
hypoxemia, cyanosis, clubbing
inspiratory crackles

A

idiopathic pulmonary fibrosis

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5
Q

CT findings

  • bilateral basilar-predominant reticulation and bronchiectasis
  • bilateral subpleural honeycomb cysts
A

idiopathic pulmonary fibrosis

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6
Q

chronic fibrosing interstitial lung disease with high mortality

A

idiopathic pulmonary fibrosis

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7
Q
  • female
  • non-smoker
  • dyspnea, cough of several months duration
A

non specific interstitial pneumonia

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8
Q
  • interstitial fibrosis and inflammation
  • lung architecture preserved
  • no honeycomb/fibroblast foci
A

non specific interstitial pneumonia

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9
Q

temporal homogenity

A

non specific interstitial pneumonia

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10
Q
  1. Patchwork of interstitial fibrosis
  2. septal distribution
  3. dense fibrosis/honeycombing
  4. fibroblast foci
A

UIP

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11
Q

inflammatory reaction of the lung to inhaled dust/mineral particles

A

pneumoconiosis

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12
Q

proinflammatory cystalling hydrated silicates

A

asbestos

pneumoconiosis

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13
Q

golden brown beaded rods with translucent center

A

ferruginous body

asbestos pneumoconiosis

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14
Q

caused by inhalation of proinflammatory crystalline sillicon dioxide

A

silicosis

pneumoconiosis

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15
Q

most prevalent occupation disease worldwide

concrete, stone cutting, sand blasting, hard rock mining

A

silicosis

pneumoconiosis

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16
Q

pneumoconiosis causes activation of

A

inflammasome

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17
Q

bright crystals under polarized light

A

silicosis

pneumoconiosis

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18
Q
  • alveolar proteinosis
  • cholesterol clefts
  • eosinophilic globules
A

acute silicosis

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19
Q

inhaled carbon dust engulfed by alveolar or interstitial macrophages

A

anthracosis

coal workers pneumoconiosis

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20
Q

coal macules and nodules consisting of carbon laden macrophages and scar

A

simple coal workers pneumoconiosis

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21
Q
  • large scars with dense collagen and black pigment
  • progressive massive fibrosis
A

complicated coal workers pneumoconiosis

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22
Q

granulomatious interstitial lung diseases

2

A
  • sarcoidosis
  • hypersensitivity pneumonitis
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23
Q
A

sarcoidosis

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24
Q
  • multi-nucleated giant cells
  • epithelioid
  • non-necrotizing
  • hyalinizing fibrosis
A

sarcoidosis

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25
* high ACE level * hypercalcemia * hypercalciuria
sarcoidosis
26
from immune reactiong provoked by inhaled antigen in susceptible individuals
hypersensitivity pneumonitis
27
* increased CD4 and CD8 T lymphocytes * non-necrotizing granulomas * antigen specific IgG antibodies * complement and Ig deposits
hypersensitivity pneumonitis
28
* insidious onset SOB, cough, weight loss, exercise intolerance * acute episodes following inhalation of irritant w/ fever, cough, elevated WBC
hypersensitivity pneumonitis
29
* mosaic perfusion * BAL fluid >20% lymphocytes
hypersensitivity pneumonitis
30
interstitial poorly formed non-necrotizing granulomas
hypersensitivity pneumonitis
31
characterized by proliferation of Langerhans cells
pulmonary langerhans cell histiocytosis
32
* smoking related * BRAF or MPK connection
pulmonary langerhans cell histiocytosis
33
* peribronchial nodules on CT, upper lobe predominate * bird beak or tennis racket on electron microscopy
pulmonary langerhans cell histiocytosis
34
eosinophilic granuloma
pulmonary langerhans cell histiocytosis
35
CD1a, S100, Langerin positive
pulmonary langerhans cell histiocytosis
36
generally improves after smoking cessation, barring BRAF/MPK mutation
pulmonary langerhans cell histiocytosis
37
airspace filling lung diseases | 2
* pulmonary alveolar proteinosis * cryptogenic organizing pneumonia
38
* positive periodic acid stain * accumulation of surfactant in airspaces
pulmonary alveolar proteinosis
39
* dyspnea * productive cough * gelatinous sputum
pulmonary alveolar proteinosis
40
# CT finding crazy paving
pulmonary alveolar proteinosis
41
whorled lamellar bodies in type 2 pneumocytes on electron microscopy
pulmonary alveolar proteinosis
42
* polypoid branching plugs (Masson bodies) * mild inflammation * preserved architecture
organizing pneumonia
43
* subacute cough with dyspnea * patchy bilateral ground glass opacities * idopathic
cryptogenic organizing pneumonia
44
destruction of bronchial walls by recurrent inflammation
bronchiectasis
45
irreversible dilation of bronchi from inflammation and destruction of bronchial walls following prolonged infections/obstructions
bronchiectasis
46
unopposed action of elastases damaging alveolar tissue
emphysema
47
bronchial mucosa damage associated with eosinophils
bronchial asthma
48
destruction of the walls of distal airspaces without prominent fibrosis
emphysema
49
associated with nasal polyps, chronic rhinitis, severe asthma and intolerance to aspirin
drug induced asthma
50
chronic productive cough without cause for > 3months in a 2 year period
chronic bronchitis
51
90% of all cases occur in smokers
chronic bronchitis
52
* hypertrophy of bronchial submucosal glands and hyperplasia of goblet cells * excessive mucus production and airway obstruction
chronic bronchitis
53
thickening of the bronchial epithelial basement membrane and hypertrophy of bronchial smooth muscle
atopic asthma
54
contact with allergen results in degranulation of mast cells and release of histamines
atopic asthma
55
dilation of respiratory bronchioles
centrilobar emphysema
56
bronchial dilation with inflammatory destruction
bronchiectasis
57
most patient clinically diagnosed with emphysema younger than 40
A1AT deficiency
58
* charcot leyden crystals * curshmann spirals * inflammatory cells in mucus
atopic asthma
59
marked thickening of pulmonary arteries
pulmonary hypertension
60
will have characteristics of both obstructive and restrictive
pulmonary hypertension
61
destruction of tissue in alveolar wall
emphysema
62
fibrosis of alveolar wall
restrictive diseases
63
non-necrotizing granulomas with multisystem involvement
sarcoidosis
64
increased susceptibility to mycobacterium
silicosis
65
most prevalent occupational disease worldwide
silicosis
66
hypersensitivity pneumonitis caused by inhalation of actinomycete spores
farmer lung | pneumonitis
67
neoplastic spindle and epitheliod cells that invade adipose tissue
asbestos
68
polypoid plugs of organizing connective tissue
cryptogenic organizing pneumonia
69
in-alveolar accumulation of granular eosinophilic material due to build up of surfactant
pulmonary alveolar proteinosis
70
hyaline membranes lining alveolar space
diffuse alveolar damage
71
abnormal dilation of distal airspaces
emphysema
72
temporally heterogenous fibrosis with fibroblast foci and interstitial fibrosis
UIP
73
firm, tan mass encasing the pleura
malignant meothelioma
74
diaphragmatic calcified plaques
mesothelioma
75
localized bronchial dilation due to chronic or recurrent infection
bronchiectasis
76
immature dendritic cells with grooved, identical nuclei
langerhans
77
positive stain for S100 and CD1a
langerhans
78
after quitting smoking, patients with Langerhans cell histiocytosis
usually recover

CP Test 3 (17 decks)

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