B.3 STEATOHEPATITA NON ALCOOLICA

Question 1

Def. NASH:

Answer 1

-CARACT PRIN inflamatie, fibroza si steatoza hepatica la persoane care NU CONSUMA ALCOOL.

Question 2

FACT ETIOLOGICI AI NASH sunt:

Answer 2

• dz tip II
• Obezitatea
• hipertrigliceridemia
• cons cronic de medicamente: Amiodarona, Diltiazem, Tamoxifen

Question 3

NASH PATOGENIE

Answer 3

• Aport crescut
• tg depunere -> steatoza
• betaoxid ac grasi-> inflam plus liza hepatocitara plus FIBROZA.

Question 4

Aspect histologic:

Answer 4

-steatoza vacuolara-> inflam. Si fibroza (corpii Mallory)-> inflam lobulara si perisinusoidala-> ciroza

Question 5

Paraclinic:

Answer 5

-gamaGT crescut
-cresc transurile de 1-3xVN usor-moderat.
-FAL crescut.
Investig. Fact etiologici:
-glicemie, trigliceride.

Question 6

Ecografia hepatica:

Answer 6

-bright liver, hiperecogenitate cu atenuare posterioara dat. Incarcarii grase hepatice pana la ciroza.