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Year 1- PoD > Antivirals > Flashcards

Antivirals Flashcards

1
Q

How do most Anti-herpes drugs work?

A

Theyre nucleoside analgues that interfere with nucleic acid synthesis

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2
Q

What anti-herpes drugs arnt nucleoside analagues?

A

Foscarnet & Cidofovir

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3
Q

Name all the anti-herpes nucleoside analogues

A

Aciclovir
Famciclovir
Vacciclovir
Ganciclovir
Valganciclovir (pro-ganciclovir)

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4
Q

What are the 3 categories of Anti-HIV drugs?

A

Nucleoside analogue
Non-nucleoside reverse transcriptase inhibitor
Protease Inhibitor

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5
Q

What are the anti-viral nucleoside inhibitors?

A

Zidovudine (ZDV, AZT)

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6
Q

What are the non-nucleotide reverse transcriptase inhibitors?

A

Nevirapine

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7
Q

What are the protease inhibitors?

A

Saquinovir

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8
Q

What drugs are used for Viral respiratory infections & which is a nucleoside analogue?

A

Oseltamavir
Zanamavir
Ribavarin (nucleoside analogue)

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9
Q

What are the 4 anti-virals for chronic HEP B or C?

A

Lamivudine
Adefovir Dipivoxil
Ribavarin
Interferon-alpha

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10
Q

Which chronic HEPB/C drug is a nucleoside analogue?

A

Lamivudine

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11
Q

Which antivirals target HSV?

A

Aciclovir
Famciclovir
Valaciclovir
Foscarnet

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12
Q

How would you treat shingles?

A

Famciclovir & valaciclovir

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13
Q

What would treat Varicella-Zoster Virus VZV?

A

Aciclovir
Foscarnet

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14
Q

How do you treat CMV?

A

Cidofovir
Valganciclovir
Ganciclovir
Foscarnet

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15
Q

What does foscarnet treat?

A

All 3 herpes viruses bar EBV

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16
Q

What does cidofovir treat?

A

CMV retinitis

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17
Q

What does aciclovir treat?

A

HSV & VZV

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18
Q

What does famciclovir & valciclovir treat?

A

HSV & shingles

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19
Q

What does Ganciclovir & valanciclovir treat?

A

CMV

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20
Q

How can aciclovir be given?

A

Orally
IV
Topically

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21
Q

Why would you avoid Aciclovir in someone with renal impairment?

A

It leads to neurological toxicity

22
Q

How are famciclovir & valciclovir given?

23
Q

How do we give ganciclovir & valganciclovir?

A

Ganciclovir - IV
Valganciclovir - Orally

24
Q

Whats dangerous about ganciclovir & Valganciclovir?

A

They have bone marrow toxicicty & require constant blood count monitoring

25
Why do we only use Foscarnet in serious infections?
It can only be iven IV And is extremely nephrotoxic
26
How is HIV treated?
With combination therapy of: Zidovudine Nevirapine Saquinavir
27
All HIV drugs are quite toxic but what does zidovudine specifcally cause?
Anaemia & Neutropenia (selective depression of neutrophil cell line)
28
Which chronic HEP B/C drug is part of the host immune response as well?
Interferon-alpha
29
How do we administer interferon-alpha?
Subcutaneous
30
Is interferon-alpha a safe treatment?
Not really its got serious side effects
31
How would we use ribavarin?
Orally to treat Chronic HEP C Inhalation to treat RSV
32
What drug treats both HIV & HEP B?
Lamivudine
33
How would we administer Lamivudine?
ORally
34
Which drug treats purely HEP B & how do we take it?
Adefovir Dipivoxil taken orally will treat HEP B
35
What two drugs are used for Influenza A/B?
Zanamavir Oseltamavir
36
Which antivirals treat HSV?
Aciclovir Famciclovir Valaciclovir Foscarnet
37
Which antivirals treat CMV?
Ganciclovir Valganciclovir Cidofovir Foscarnet
38
Which antivirals treat VZV?
Aciclovir Foscarnet
39
What drugs treat HIV?
Zamivudine Sauinovir Nevirapine Lamivudine
40
What drugs treat HEP B?
Interferon-alpha Adefovir Dipivoxil Lamivudine
41
What treats respiratory syncitial virus?
Ribavarin
42
What treats chroninc HEP C?
Ribavarin
43
What treats influenza A/B?
Oseltamavir Zanamavir
44
Which antivirals are orally prescribed?
Adefovir Dipixoil (HEP B) Lamivduine (HEP B) Ribavarin (HEP C) Valganciclovir (CMV) Aciclovir (HSV) Valciclovir (HSV & shingles) Famciclovir (HSV & shingles)
45
What antivirals are iven IV?
Aciclovir (VSV) Ganciclovir (CMV) Foscarnet (HSV,VSV,CMV)
46
What antivirals are given topically?
Aciclovir (HSV)
47
What antiviral causes neurological toxicity?
Aciclovir
48
What antiviral causes Bone marrow toxiicty?
Ganciclovir Valganciclovir
49
Which antibirals are highly nephrotoxic?
Foscarnet
50
Which antiviral can cause neutropenia?
Zidovudine, also causes anaemia

Year 1- PoD (47 decks)

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