Antiviral Pharm

Question 1

MOA of acyclovir

Answer 1

interferes with viral nucleic acid synthesis
prevents virus from binding to cells so virus cannot get into cells –> preventing viral replication
stimulates the body’s immune system to kill the virus

Question 2

what is acyclovir commonly used for

Answer 2

herpes

Question 3

adverse effects of acyclovir

Answer 3

GI distress, renal impairment, seizures, ITP, tissue necrosis (IV)

Question 4

nursing considerations of acyclovir

Answer 4

NOT a cure, treats symptoms and frequency of outbreaks
may require multiple treatments

Question 5

what is oseltamivir used for

Answer 5

prophylaxis and to treat flu (onset of 48 hr)
immunocompromised after known exposure to influenza A and B

Question 6

MOA of oseltamivir

Answer 6

inhibit neuraminidases in influenza viruses

Question 7

SE of oseltamivir

Answer 7

n/v
seizures
renal impairment

Question 8

what is ganciclovir used for

Answer 8

cytomegalovirus (CMV)

Question 9

MOA of ganciclovir

Answer 9

inhibits viral DNA polymerases resulting in chain termination

Question 10

Adverse effects of ganciclovir

Answer 10

Black box: hematologic toxicity, fertility impairment, fetal toxicity, carcinogenesis

Question 11

nursing considerations of ganciclovir

Answer 11

do not give with imipenem/cilastatin –> seizure potential

watch kidneys if given with other nephrotoxic drugs