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Pharmacology - ADRN.114 > Antiseizure Medications > Flashcards

Antiseizure Medications Flashcards

rotation 3 - week 2

1
Q

_________ is involved in the coordination of impulses and responses.

A

Dopamine

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2
Q

Gamma-aminobutyric inhibits nerve activity and is important in preventing
overexcitability or stimulation such as ________ activity.

A

seizure

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3
Q

____________ important in arousal and sleep and in preventing depression and promoting
motivation

A

serotonin

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4
Q

The drug class ________, are used to treat seizures by decreasing excitability and hyper-excitability. Some examples of this drug class include __________ + _______________.

A

Hydantoins;

Phenytoin (Dilantin) + Fosphenytoin

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5
Q

What are the 4 major side effects to monitor for with antiseizure meds. like henytoin or Dilantin?

A

-steven Johnson syndrome
-gingival hyperplasia
-liver toxicity
-bone marrow suppression

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6
Q

Barbiturates and barbiturate like drugs decrease excitability and hyperexcitability. What are 2 drugs that belong to this class?

A

-phenobarbital
-primidone

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7
Q

what are the general side effects of most antiepileptic or sedative drugs?

IE. hydantoins, barbiturates, benzodiazepines,

A

-CNS depression
-lethargy
-fatigue
-constipation
-dry mouth
-drowsiness
-anorexia
-arrythmias
-changes in BP

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8
Q

true or false?
Barbiturates can lead to physical dependence and cause withdrawal symptoms.

A

true

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9
Q

What are 2 side effects of Phenobarbital + Primidone related to the bladder and sexual function that may occur?

A

urinary retention and decreased libido

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10
Q

Phenobarbital, Primidone (barbiturates) can decrease the effects of _________, which will make it less effective in preventing blood clots?

A

warfarin

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11
Q

true or false?
If you drink alcohol while on a barbiturate or benzodiazepine, you could cause a further depression of the CNS.

A

true

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12
Q

______________ causes muscle relaxation and relieve anxiety without substantially affecting cortical function.

A

benzodiazepines

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13
Q

Clobazam, clonazepam, diazepam belong to what drug class?

A

benzodiazepines

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14
Q

benzodiazepines are highly addictive, they should never be stopped abruptly? So how should they be stopped?

A

these drugs need to be tapered

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15
Q

What side effect should you monitor for while a patient is taking a benzodiazepine, related to the bladder?

A

urinary retention

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16
Q

Ethosuximide + methsuximide are examples of which drug class?

A

succinimides

17
Q

succinimides treat _______ seizures.

A

absent

18
Q

Drugs that modulate GABA - which means excitability is reduced and overactivity is prevented, are used to treat:

A

-prevent migraines
-absent seizures
-manic episodes

19
Q

-Diamox
-Divalproex
-Valproic acid
-Zonisamide

belong to which drug class?

A

GABA inhibitors

20
Q

hyperammonemia
thrombocytopenia and pancreatitis are 3 adverse effects associated with which drug class?

A

GABA inhibitors

21
Q

true or false?
Carbamazepine is used to treat generalized or focal seizures.

A

true

22
Q

Lamotrigine modulates excitatory neurotransmitters to treat ________.

A

seizures

23
Q

Levetiracetam is another drug used to treat seizures or _________.

A

epilepsy

24
Q

Topiramate is a drug used to treat seizure’s associated with what syndrome?

hint: chef gusteau is my mate

A

(LGS) Lennox gastaut syndrome.

25
Q

What disease is characterized by lack of coordination, tremors, rigidity and weakness of muscles?

A

Parkinson’s disease or parkinsonism

26
Q

true or false? bradykinesia develops due to trouble maintaining posture or position and difficulty performing intentional movements, while also moving extremely slow and sluggish.

A

true

27
Q

carbidopa/levodopa is a dopaminergic drug used to treat what kind of disease that affects movement due to some kind of damage or issue to basal ganglia?

A

Parkinson’s Disease

28
Q

you need to monitor patients ________ status who are on dopaminergic drugs because of the risk of HTN + prolonged QT intervals.

A

cardiac

29
Q

if a dopaminergic is taken with an MOAI, there is an increased risk of an ________ ________.

A

hypertensive crisis

29
Q

____________ are used to treat Parkinson’s due to it helping restore balance in the basal ganglia.
Some examples of drugs in this drug class include: benztropine, diphenhydramine trihexyphenidyl

A

anticholinergics

30
Q

Carbidopa/Levodopa is taken as a combination drug because one
facilitates the ___________ of the other.

A

absorption

Pharmacology - ADRN.114 (16 decks)

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