Antiinfectives Flashcards
classes of antibiotics (9)
suflonamides penicillins tetracyclines fluoroquinolones cephalosporins macrolides lincosamides nitroimidazoles antituberculosis agents
3 types of antiinfectives
antibiotics
antifungals
antivirals
sulfonamides (4)
-ind. for UTIs and cystitis Bactrim DS Septra DS Macrodantin Macrobid
UTI
urinary tract infection
cystitis
inflammation of the bladder
Bactrim DS, Septra DS
sulfamethoxazole, trimethoprim DS
- sulfonamide, not a sulfonamide
- pt. counseling: take with PLENTY of water, may cause phototoxic reactions so be careful in UV light, and finish all medication
- drug interaction between ACE inhibitors and ARBs with sulfonamides: 7-fold increase in hyperkalemia*
phototoxic reaction of Bactrim DS and Septra DS
drug is in the skin, UV light activates the drug, drug emits energy into the skin, and it burns (resembles a sunburn)
Macrodantin, Macrobid
nitrofurantoin
- sulfonamide
- pt. counseling: take WITH food, makes urine a rust color, finish all medication
phenazopyridine
- analgesic
- it is a reddish dye that has a local anesthetic effect on the urinary tract mucosa
- NOT an antibiotic- relieves burning on urination assoc. w/ UTIs, does not cure them
- pt. counseling: drink plenty of water and turns urine brownish-red color (stains clothing)
Pyridium
phenazopyridine
- analgesic
- 100mg, 200mg (Rx only)
Azo-standard
phenazopyridine
- analgesic
- 95mg (OTC)
crystalluria
excretion of crystals in the urine
penicillins (4)
-pt. counseling: finish ALL medication penicillin ampicillin amoxicillin Moxatag
penicillin
- penicillin
- take on an EMPTY stomach
ampicillin
- penicillin
- take on an ES
amoxicillin
- penicillin
- take w/o regard to meals
Moxatag
amoxicillin ER
- penicillin
- qday
tetracyclines (4)
tetracycline
minocycline
doxycycline
Periostat
tetracycline pt. counseling
- do NOT take with di- or trivalent cations b/c it will chelate with them
- cause phototoxic reactions
- finish ALL medication
chelation
formation of complexes with di- or trivalent cations
tetracycline
-tetracycline
minocycline
-tetracycline
doxycycline
-tetracycline
Periostat
doxycycline
- tetracycline
- ind. for periodontitis
- 20mg - not antibacterial at this strength
- inhibits collagenase
collagenase
enzyme that causes inflammation
periodontitis
inflammatory condition around teeth that can lead to tooth loss
oral fluoroquinolones (6)
Cipro Noroxin ofloxacin Levaquin Avelox Factive
oral fluoroquinolone pt. counseling
- finish ALL medication
- do NOT take with di- or trivalent cations
- may cause phototoxicity
- BBW: may cause achilles or other tendon rupture
- -do NOT give to pts. under 18 b/c risk for tendon rupture is higher
Cipro
ciprofloxacin
-fluoroquinolone
Noroxin
norfloxacin
-fluoroquinolone
ofloxacin
-fluoroquinolone
Levaquin
levofloxacin
-fluoroquinolone
Avelox
moxifloxacin
-fluoroquinolone
Factive
gemifloxacin
-fluoroquinolone
ophthalmic fluoroquinolones (6)
-ind. for bacterial conjunctivitis Zymaxin Ocuflox Ciloxan Besivance Vigamox Moxeza
Zymaxin
gatifloxacin
-ophthalmic fluoroquinolone
bacterial conjuctivitis
pink eye
Ocuflox
ofloxacin
-ophthalmic fluoroquinolone
Ciloxan
ciprofloxacin
-ophthalmic fluoroquinolone
Besivance
besifloxacin
-ophthalmic fluoroquinolone
Vigamox
moxifloxacin 0.5%
- ophthalmic fluoroquinolone
- TID
Moxeza
moxifloxacin 0.5%
- ophthalmic fluoroquinolone
- BID
cephalosporin facts
- if allergic to penicillins, may be allergic to cephalosporins (5% chance)
- the higher the generation, the greater the gram negative activity and the lesser the gram positive activity
- finish all medication
1st generation cephalosporins (2)
cefadroxil
Keflex
cefadroxil
-1st generation cephalosporin
Keflex
cephalexin
-1st generation cephalosporin
2nd generation cephalosporins (3)
cefaclor
Cefzil
Ceftin
cefaclor
-2nd generation cephalosporin
Cefzil
cefprozil
-2nd generation cephalosporin
Ceftin
cefuroxime
-2nd generation cephalosporin
3rd generation cephalosporins (4)
cefdinir
cefpodoxime
Spectracef
Suprax
cefdinir
- 3rd generation cephalosporin
- pt. counseling: avoid antacids while taking, oral suspension may cause red stool, do NOT refrigerate after reconstitution b/c viscosity increases greatly
cefpodoxime
-3rd generation cephalosporin
Spectracef
cefditoren
- 3rd generation cephalosporin
- take WITH food*
Suprax
cefixime
-3rd generation cephalosporin
macrolides (5)
-if allergic to one, may be allergic to all
-finish all medication
erythromycin
Biaxin
Zithromax
Z-Max
AzaSite
erythromycin
- macrolide
* take WITH food*
Biaxin
clarithromycin
- macrolide
- take WITH food*
Zithromax
azithromycin
- macrolide
- tablet: 250, 500mg
- powder for oral suspension: 100mg/5mL or 200mg/5mL - reconstituted in the pharmacy
- 1g powder packet: ind. for chlamydia - reconstituted by pt. in 60mL of water and taken as single dose
- pt. counseling: avoid antacids, can be taken with or without food
Z-Max
azithromycin ER microspheres for oral suspension
- macrolide
- 2g single dose bottle
- reconstituted in pharmacy, pt. must drink within 12 hr on ES
AzaSite
azithromycin 1% ophthalmic solution
- macrolide
- ind. for bacterial conjunctivitis
- refrigerate in pharmacy*
bacterial conjunctivitis
pink eye
lincosamides (4)
-finish all medication and all oral dosage forms may turn stool black Cleocin Cleocin Vaginal Cream Cleocin Ovules Cleocin T
Cleocin
clindamycin
- lincosamide
- capsule: 150, 300mg
- granules for oral suspension: 75mg/5mL - do NOT refrigerate after reconstitution
Cleocin Vaginal Cream
clindamycin 2% vaginal cream
- lincosamide
- ind. for bacterial vaginosis
- insert one applicatorful vaginally qHS x7D
Cleocin ovules
clindamycin 100mg vaginal suppository(capsule)
- lincosamide
- ind. for bacterial vaginosis
- insert one capsule qday X3D
Cleocin T
clindamycin 1% topical dosage forms
- lincosamide
- ind. for acne
nitroimidazoles (5)
-effective against bacteria and protozoa Flagyl MetroGel Vaginal Vandazole Vaginal MetroLotion MetroCream
nitroimidazole pt. counseling
- do NOT drink alcohol - may cause a disulfiram-like reaction (10% incidence)
- oral metronidazole + alcohol = vomiting
- -avoid alcohol for 3 days after finishing therapy
- -it is possible but not likely with other dosage forms
Flagyl
metronidazole
- nitroimidazole
- ind. for trichomoniasis
- tablet: 250, 500mg
- 250mg TID X7D or 2g as a single dose (most popular)
trichomoniasis
- infection by Trichomonas vaginalis - a protozoan
- females are symptomatic (vaginal burning/discharge), males are asymptomatic
- -MUST treat both partners or man will keep infecting the woman
MetroGel Vaginal, Vandazole Vaginal
metronidazole vaginal 0.75%
- nitroimidazole
- ind. for bacterial vaginosis
- insert one applicatorful qHS X5D
MetroLotion
metronidazole 0.75% lotion
- nitroimidazole
- ind. for rosacea
- BID
MetroCream
metronidazole 0.75% cream
- nitroimidazole
- ind. for rosacea
rosacea
skin inflammation affecting the middle third of the face
-characterized by erythema
erythema
redness
rhinophyma
swollen, bumpy nose resulting from untreated rosacea
Azelex
azelaic acid 20%
- ind. for rosacea
- BID
Finacea
azelaic acid 15%
- ind. for rosacea
- BID
Antabuse
disulfiram
- NOT an antibiotic
- ind. for alcoholism in pts. who want enforced sobriety
- inhibits aldehyde dehydrogenase which causes build up of aid aldehyde and makes pt. very sick
- do NOT start until pt. has had no alcohol for at least 12 hours; must wait 2 weeks after stopping disulfiram before drinking alcohol
antituberculosis agents (3)
-all used together
Rifadin
isoniazid
pyrazinamide
Rifadin
rifampin
- antituberculosis agent
- pt. counseling: all body secretions are discolored orange, decreases effectiveness of hormonal contraceptives (pt. will need to use alternative method), and take on an ES
isoniazid
-antituberculosis agent
pyrazinamide
-antituberculosis agent
Xifaxan
rifaximin
- antibiotic
- ind. for Travelers Diarrhea (caused by E. Coli)
- do NOT take if allergic to rifampin; structurally similar
topical antifungals (10)
-all but ciclopirox lacquer ind. for tinea corporis, tinea pedis, and tinea cruris Tinactin Lotrimin AF Loprox ketoconazole Lamisil AT econazole Ertaczo Lotrimin Ultra Mentax ciclopirox lacquer
tinea corporis
ringworm
tinea pedis
athlete’s foot
tinea cruris
jock itch
tinea unguium, onychomycosis
fungal infection of the nail
Tinactin
tolnaftate
-topical antifungal
Lotrimin AF
clotrimazole
-topical antifungal
Loprox
ciclopirox
-topical antifungal
ketoconazole
-topical antifungal
Lamisil AT
terbinafine
- topical antifungal
- SALAD with Lamictal- lamotrigine
econazole
-topical antifungal
Ertaczo
sertaconazole
-topical antifungal
Lotrimin Ultra, Mentax
butenafine
-topical antifungal
ciclopirox lacquer
- topical antifungal
- ind. for onychomycosis
- paint the nail at bedtime, then paint over previous coats qHS X7D
- only 12% of pts. see improvement after 1yr of Tx
oral antifungal classes
triazoles
imidazoles
triazoles (4)
Diflucan
Sporanox
Vfend
Noxafil
Diflucan
fluconazole
-triazole
Sporanox
itraconazole
-triazole
Vfend
voriconazole
- triazole
- take on ES
Noxafil
posaconazole
- triazole
- take WITH food
imidazoles (3)
ketoconazole
clotrimazole
miconazole
ketoconazole oral
- imidazole - oral antifungal
- needs to be taken 2hr before antacids, the lower the pH the better it is absorbed
- sometimes given for skin infections, if you work out about 2hr after taking pill it will concentrate on the skin if you sweat
clotrimazole
-imidazole
miconazole
-imidazole
Grifulvin V, Gris-PEG
griseofulvin
- oral antifungal
- take WITH food