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Dispensing F13 Exam II > Antihyperlipidemics > Flashcards

Antihyperlipidemics Flashcards

0
Q

hyperlipidemia

A

elevated serum cholesterol

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1
Q

antihyperlipidemic classes

A 
-ind. for hyperlipidemia
HMG-CoA reductase inhibitors
fibric acid derivatives
bile acid sequestrants
cholesterol absorption inhibitors
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2
Q

optimum cholesterol levels

A
  • HDL: >40mg/dL (60mg/dL is better, negative risk factor)

- LDL (healthy, no risk factors): <150mg/dL

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3
Q

goal of cholesterol therapy

A
  • low LDL and triglycerides, high HDL
  • -high HDL helps to lower LDL
  • -raise HDL non-pharmacologically by aerobic exercise
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4
Q

hypertriglyceridemia

A

elevated triglyceride levels in the blood

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5
Q

HMG-CoA reductase inhibitors (8)

A

-a.k.a. statins
-enzyme necessary for cholesterol formation
Lescol
Pravachol
Zocor
Lipitor
Crestor
Livalo
Mevacor
Altoprev

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6
Q

HMG-CoA reductase inhibitor pt. counseling

A
  • may cause muscle pain or weakness or rhabdomyolysis
  • avoid in pregnancy
  • best to take in pregnancy
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7
Q

Lescol

A

fluvastatin

-HMG-CoA reductase inhibitor

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8
Q

Pravachol

A

pravastatin

-HMG-CoA reductase inhibitor

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9
Q

Zocor

A

simvastatin

-HMG-CoA reductase inhibitor

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10
Q

Lipitor

A

atorvastatin

-HMG-CoA reductase inhibitor

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11
Q

Crestor

A

rosuvastatin

-HMG-CoA reductase inhibitor

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12
Q

Livalo

A

pitavastatin

-HMG-CoA reductase inhibitor

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13
Q

Mevacor

A

lovastatin IR

  • HMG-CoA reductase inhibitor
  • take WITH food*
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14
Q

Altoprev

A

lovastatin ER

  • HMG-CoA reductase inhibitor
  • take on ES*
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15
Q

fibric acid derivatives (6)

A 
-mainly used to lower triglycerides
Lopid
Tricor
Triglide
Lofibra
Antara
Trilipix
16
Q

fibric acid derivative pt. counseling

A

-do not take with statins because it increases risk of rhabdomyolysis EXCEPT Trilipix

17
Q

Lopid

A

gemfibrozil

  • fibric acid derivative
  • take on ES*
18
Q

Tricor, Triglide, Antara

A

fenofibrate

-fibric acid derivative

19
Q

Lofibra

A

fenofibrate

  • fibric acid derivative
  • take WITH food*
20
Q

Trilipix

A

fenofibric acid

  • fibric acid derivative
  • active metabolite of fenofibrate
21
Q

bile acid sequestrant MOA

A

-form complexes with bile acids in the GI Tract, complexes are excreted in the stool, then body uses own cholesterol to make more bile acids which lowers serum cholesterol

22
Q

bile acid sequestrant pt. counseling

A
  • are all powders for oral suspension, so mix with water and drink
  • very constipating
  • take with plenty of water
  • take other medications 1 hour before or 4 hours after because these bind with other drugs and interfere with their absorption
23
Q

bile acid sequestrants (4)

A

Questran
Prevalite
Colestid
Welchol

24
Q

Questran, Prevalite

A

cholestyramine

-bile acid sequestrant

25
Q

Colestid

A

colestipol

-bile acid sequestrant

26
Q

Welchol

A

colesevelam

  • bile acid sequestrant
  • also ind. for type II diabetes as adjunctive therapy
  • daily dose: 3.75g/day
  • 625mg tablet: 6 tabs qday or 3 tabs BID
  • powder for oral suspension: 3.75g qday or 1.875g BID
27
Q

Zetia

A

ezetimibe
-cholesterol absorption inhibitor - prevents cholesterol absorption in the intestines which lowers total blood cholesterol level

28
Q

Niaspan

A

niacin

  • antihyperlipidemic
  • take 325mg aspirin or 200mg ibuprofen 30 minutes before taking to avoid flushing
29
Q

Advicor

A

lovastatin IR, niacin

  • HMG CoA-reductase inhibitor, antihyperlipidemic
  • take WITH food*
30
Q

Simcor

A

simvastatin, niacin

  • HMG CoA-reductase inhibitor, antihyperlipidemic
  • take WITH food*
31
Q

Lovaza

A

omega-3 fatty acids

  • antihyperlipidemic
  • daily dose: 4g
  • 1g capsule: 4 caps qday or 2 caps BID
  • Warning: if allergic to peanuts, do NOT take* contains soybean oil

Dispensing F13 Exam II (18 decks)

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