Antidepressants Flashcards
antidepressant onset and BBW
- delayed onset, won’t see full effect for about 3 weeks
- BBW: increased risk of suicidal thinking in pts. under 24 with depreassion or other psychiatric disorders
dysthymia
chronic, low-grade depression
anhedonia
inability to experience pleasure
antidepressant classes (7)
triazolopyridines tetracyclines aminoketones phenylpiperazines selective serotonin and norepinephrine reuptake inhibitors selective serotonin reuptake inhibitors tricyclics
triazolopyridines (1)
Oleptro
Oleptro
trazodone ER tablet
- triazolopyridine
- ind. ONLY for depression: off-label use for insomnia)
- scored so OK to be cut, technology is Contramid
- tablet IR tablet is generic only: trazodone
tetracyclines (2)
Remeron
Remeron SolTab
Remeron
mirtazapine tablet
- tetracycline
- ind. ONLY for depression
Remeron SolTab
mirtazapine ODT
- tetracycline
- ind. ONLY for depression
aminoketones (3)
Wellbutrin
Wellbutrin SR
Wellbutrin XL
Wellbutrin
bupropion
- aminoketone
- ind. for depression and SAD
- TID
SAD
seasonal affective disorder
Wellbutrin SR
bupropion
- aminoketone
- ind. for depression and SAD
- BID
Wellbutrin XL
bupropion
- aminoketone
- ind. for depression and SAD
- qday
Zyban
bupropion
- aminoketone
- ind. ONLY for smoking cessation
nefazodone
- phenylpiperazine
- ind. ONLY for depression
selective serotonin and norepinephrine reuptake inhibitors (4)
-SNRIs
-raise serotonin and NE levels in the brain
Effexor
Pristiq
Cymbalta
Savella
Effexor
venlafaxine
- SNRIs
- ind. for depression, anxiety, and panic disorder
Pristiq
desvenlafaxine
- SNRIs
- ind. ONLY for depression
- active metabolite of venlafaxine
Cymbalta
duloxetine
- SNRIs
- ind. for depression, anxiety, fibromyalgia, DPN, and chronic musculoskeletal pain
Savella
milnacipran
- SNRIs
- ind. ONLY for fibromyalgia
selective serotonin reuptake inhibitors (7)
-SSRIs
-raise serotonin levels
Prozac
Paxil
Pexeva
Zoloft
Luvox CR
Celexa
Lexapro
SSRIs ind. as a class (6)
depression OCD anxiety panic disorder PTSD PMDD
Prozac
fluoxetine
-SSRI
Paxil
paroxetine HCl
-SSRI
Pexeva
paroxetine mesylate
- SSRI
- cannot be switched with Paxil because they are different salt forms
Zoloft
sertraline
-SSRI
Luvox CR
fluvoxamine
- SSRI
- ind. ONLY for OCD, does NOT treat depression
Celexa
citalopram
- SSRI
- racemic
drugs ind. for PMDD
fluoxetine
sertraline
Paxil
Yaz (drospirenone, ethinyl estradiol)
tricyclics (6)
pt. counseling: may cause drowsiness, avoid alcohol, use good dental care, may cause dry mouth amitryptyline Anafranil doxepin Norpramin Tofranil Pamelor
amitriptyline
-tricyclic
Anafranil
clomipramine
- tricyclic
- ind. ONLY for OCD
- SE: 5% of people have orgasm when yawn
doxepin
- tricyclic
- ind. ONLY for insomnia
Norpramine
desipramine
-tricyclic
Tofranil
imipramine
-tricyclic
Pamelor
nortriptyline
-tricyclic
Evoxac, Salagen
- cholinergic agents
- ind. for xerostomia and Tx of Sjogren’s Syndrome symptoms - autoimmune disease often in elderly women that can dry mucus membranes and cause xerostomia
Lexapro
escitalopram
- SSRI
- only contains the “S” isomer