Antifongiques Flashcards

1
Q

Donner les 4 classes d’antifongiques

A
  • Polyènes: amphotéricine B
  • Azolés po ou IV
  • Echinocandines IV (caspofungine)
  • 5-Flucytosine
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2
Q

Toxicité de l’amphotéricine B?

A

néphrotoxicité: tubulaire

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3
Q

Sur quels champi est active l’ampho B?

A

levures et champi filamenteux (ex: Aspergillus)

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4
Q

Le fluconazole couvre t il l’aspergillus?

A

Non

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5
Q

Quels champi couvre le fluconazole?

A

Candida et Cryptocoques

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6
Q

Quels champi couvre le voriconazole?

A

spectre du fluconazole = candida, cryptocoques

+ Aspergillus (ttt de 1ère intention)

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7
Q

spectre du posaconazole?

A

voir cours

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8
Q

Spectre des échinocandines?

A

Candida Aspergillus

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9
Q

Indication de la 5-flucytosine?

A

Jamais seule!!! En association dans le ttt de la phase initiale de la cryptococcose

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10
Q

Traitement des candidoses?

A

échinocandine en probabiliste, relai par le fluconazole si le candida y est sensible

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