Anti-psychotics Flashcards
Anti-psychotics are divided up into how many groups
2- Typical and Atypical
The typical anti-psychotics are then further divided into
High and low potency
What are the low potency anti-psychotics
Chlorpromazine, Thoridizine
What are the characteristic side-effects of Typical antipsychotics that are low potency (chlorpromazine, Thoridizine)
Non-neurologic/ Anti-cholinergic side-effects such as dry mouth, constipation, etc…)
What are the high potency cholinergics we need to know
Try to Fly High
Triflouperazine
Fluphenazine
Haloperidol
Side effects of the high potency cholinergics
mostly neurologic: , extrapyramidal symptoms such as movement disorders, tardive dyskinesia,
ndocrine side-effects of typical antipsychotics include
hyperprolactinemia (due to dopamine receptor antagonism)
Neuroleptic Malignant syndrome
F- Fever E- Encephalopathy V- Vitals unstable E- Elevated Enzymes (CK, myoglobin) R- Rigid muscles
Biological basis of schizophrenia
hyperactivation of Dopamine systems
Typical antipsychotics clinical potency correlates with in vitro inhibition of D2 receptor binding
Atypical antipsychotics physical potency revolves mostly around 5-HT2 affinity
ok
What are the atypicals
Atypical OLd CLOSets QUIETly RISPER A to Z
Olanzapine, clozapine, quetiapine, risperiodone, aripiprazole, ziprasidone
Only approved agent for use in kids
Risperidone
Aripiprazole is unique why
It is a D@ partial agonist, has a lower incidence of side-effects.
Ziprasidone side effect
QT prolongation
Agranulocytosis
Clozapine may cause it. Requires weekly WBC monitoring
