Anti-Anxiety Flashcards
All of the benzodiazepines end in ….
-am except for chlordiazepoxide and clorazepate
Benzodiazepine MOA
Aloosteric agents, modify the response of the GABA receptor to its endogenous ligand and potentiate the effects of GABA
Which of the Benzos have very short half-lives and therefore do not serve a great deal of purpose in regards to anxiety treatment?
Alprazolam, Oxazepam, Lorazepam
Abrupt discontinutation of a benzo can lead to
Withdrawl reactions
Remember that the severity and onset are inversely related to duration of action
Shorter duration of action (half-life) means greater severity of withdrawal symptoms
What are the symptoms of withdrawal from benzos
tremor, sweating, insomnia, tachycardia
DOC for panic attacks
Alprazolam
Benzo used for muscle relaxation
Diazepam- inhibits monosynaptic reflexes in the spinal cord
Alcohol withdrawal
Chlordiazepoxide and diazepam
Alcohol withdrawal in those with Liver problems
Lorazepam
Mechanisms by which tolerance may develop
- Receptor uncoupling
- Receptor subunit downregulation
- Sensitization of glutamatergic system (stimulatory)
- crosstalk from other G protein systems
DO NOT DRINK ON BENZOS ….THIS can lead to excess sedation and may kill you
ok
How does Busipirone work
Suppreses serotonergic effects while enhancing noradrenergic and dopaminergic effects
Propanolol
used for stage fright. its a better blocker….prevents heart rate from rising
