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PHARMACOLOGY > Anti Jnflammatory > Flashcards

Anti Jnflammatory Flashcards

1
Q

• Inhibit the biosynthesis of prostaglandin
• relieve pain (analgesic)
• reduce elevated body temperature (antipyretic)
• Inhibit platelet aggregation (anticoagulant)

A

ANTI - INFLAMMATORY

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2
Q

Cox- is short for Cyclooxygenase
- is an enzyme that converts arachidonic acid
into Prostanoids and related compounds
- is an enzymes that is required for
prostaglandin and thromboxane synthesis

A

NON STEROIDAL ANTI - INFLAMMATORY DRUGS
(NSAIDs)

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3
Q

promotes the repair and growth of skeletal muscle tissue via conversion to prostaglandin.

A

Arachidonic Acid

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4
Q
  • are a family of chemicals that support the blood
    clotting functions of platelets.
  • protect the lining of the stomach from the
    damaging effects of acid.
  • promote inflammation that is necessary for
    healing but also results in pain and fever.
A

Prostaglandin

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5
Q

mimic the effects of corticosteroids (cortisone)

A

NON STEROIDAL ANTI - INFLAMMATORY DRUGS

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6
Q

aspirin and aspirin-like drugs that inhibit the enzyme COX, which is needed for the
biosynthesis of the prostaglandins
• may be called prostaglandin inhibitors

A

NON STEROIDAL ANTI - INFLAMMATORY DRUGS

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7
Q

There are seven groups of NSAIDs:

A
  1. Salicylates
  2. Para-chlorobenzoic acid derivatives
  3. Phenylacetic acids
  4. Propionic acid derivatives
  5. Fenamates
  6. Oxicams
  7. Selective COX-2 inhibitors
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8
Q

NSAIDs available Over-the- Counter:

A
  1. Aspirin (Bayer Bufferon, Eycedin)
  2. Ibuprofen (Advil, Motrin IB)
  3. Naproxen (Aleve)
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9
Q

Also called acetylsalicylic acid

Developed in 1899 by Adolph Bayer, making it the oldest anti-inflammatory agent.

antiplatelet drug for patients

A

Salicylate

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10
Q

One of the first NSAIDs introduced was
indomethacin (Indocin), a para chlorobenzoic
acid.

● It is used for rheumatoid arthritis, gouty arthritis,
and osteoarthritis and is a potent prostaglandin
inhibitor

A

Para - Chlorobenzoic Acid

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11
Q

the first injectable NSAID

Ketorolac is recommended for short-term

management of pain.

A

Phenylacetic Acid Derivatives

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12
Q

Diclofenac sodium

A

Phenylacetic Acid Derivatives

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13
Q

relatively new group of NSAIDs.

● aspirin-like but have stronger effects and create
less Gl irritation.

A

Propionic Acid

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14
Q

for acute and chronic arthritic conditions.

A

Fenamates

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15
Q

Piroxicam (Feldene), is indicated for
long-term arthritic conditions such as rheumatoid
arthritis and osteoarthritis.

A

oxicam

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16
Q

stick (often derivative
referred to as a “fentanyl lollipop”). This form is 80-100 times more potent than morphine and intended for use by cancer patients and patients that have become analgesic properties than other
tolerant to opioids.

A

Fentanyl

17
Q

drugs of choice for patients with severe arthritic conditions who need high doses of an anti - inflammatory drug because large doses of NSAIDs may cause
tinnitus, and pruritus.
peptic ulcer and gastric bleeding inhibitor.

A

Selective COX-2 Inhibitors

18
Q

used to treat refractory
rheumatoid arthritis

A

Immunosuppressive Agents

19
Q

works by reducing the amount of uric acid made by body cells. In gout, this helps prevent uric acid crystals building up in the joints.

A

Allopurinol

20
Q

A drug derived from alkaloids of the opium poppy

A

Opiate

21
Q

A class of drugs that includes opiates, synthetic drugs, and opiopeptins that mimic opiates

A

Opioid

22
Q

A naturally occurring peptide that act on opioid receptors in the body

A

Endorphins

23
Q

There are 3 classical opioid receptors located in the
central and peripheral nervous systems:

A
  1. Mu
  2. Kappa
  3. Delta
24
Q

● When used in combination with selective
serotonin reuptake inhibitors
● Potentially Fatal

A

Meperidin
Serotonin Syndrome

25
Q

● When used in combination with MAO Inhibitor
● May result in seizure or coma

A

Hyperpyrexia Syndrome

26
Q

Synthetic Mu Receptor pure competitive antagonist
blocker

A

Naloxone

27
Q

Will not antagonize other Opioids, may be additive

A

NALBUPHINE

28
Q

Helpful when converting from one opioid to another

A

Equianalgesic dosing

29
Q

is the gold standard comparator for equianalgesic dosing.

A

Morphine

30
Q

Opioids may decrease the patient’s cough reflex.
Therefore, it is important to have the patient turn, cough, and deep breath regularly to prevent

A

atelectasis.

31
Q

Give the opioid drug at least__ minutes prior
to activities or painful procedures.

A

30-60

PHARMACOLOGY (22 decks)

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