Anti-epileptic, anti Parkinson's, and anti Alzheimer drugs Flashcards
True or false: it is abnormal for children to have seizures w/o having epilepsy. Explain your reasoning.
F: children can have fever induced seizures
-barbituates
-hydantoins
-Iminostilbenes
-2nd/3rd gen antiepileptics
These are ____ drugs
AEDs
AED therapies require:
serum drug testing
AED drugs carry a black box warning for
suicidality
Barbituates for epilepsy (phenobarbitol and primidone) have a _____ half life and carry what contraindications
long
-contra: heart meds, liver/kidney disease, birth control
Restlessness is a symptom of barbituates: t/f
T
Hydantoins (phenytoins) are given __ and compete with _____ ______ drugs like ______.
IV, protein bound, warfarin
Phenytoin cannot be taken with
-other protein bound drugs
What lab would you assess if giving hydantoins? How would you give it IV?
-monitor albumin levels
-slow IV into large vein w large needle, flushed before/after
Phenytoin side effects (hint: werewolf)
-bad teeth
-acne
-increased fat tissue in face
-hirsutism (hair growth
Iminostilbenes drugs include carbamazepine and oxcarbazepine–how are the two different?
Carb: hepatic enxyme inducer–can build tolerance
Ox: is not a HEI
A pt says they are taking CARBAMAZEPINE for absent seizures with a glass of gfruit juice in the AM. Your first priorities are to…
-tell them to STOP immedieatly that is bad–no gfruit and only for partial/general seizure
Gabapentin is used for treatment of ______ seizures and __________. It carries ___ symptoms
partial, neuropathy.
-GI
LyriCa MOA and use
MOA: binds to Ca channels, slows shit down
-“add on” therapy for seizure, neuropathy, fibromyalgia
What seizure meds are protein bound?
-hydantoins
-valproic acid
A pt says they take their valproic with a can of diet coke every morning. What is the pts diagnosis? what is your response?
-BPD, generalized or partial seizure
-dont do that
Parkinson’s symptoms (TRAP)
Tremor
Rigidity
Akinesia (slow movement)
Postural instability
Drugs for parkinson’s increase ________ and reduce the effects of_______
dopamine, Ach (acetylcholine).
Selegine and rasagiline treat ______. What is their class?
Parkinson’s
-MOAIs: increase dopamine
MAOIs, when taken with cheese or wine, can cause…
hypertensive crisis
Which dopamine replacement drugs cross the BBB? Which don’t? What are these used for?
doesn’t cross: levadopa
crosses: carbidopa
Parkinson’s
Patients should eat lots of protein with “dopa” drugs: t/f
F! protein can slow drug’s effects
Benztropine (an _________) is used to treat _______ because they block the effect of ___.
anticholinergic, Parkinson’s, Ach (acetylcholine).
Aricept and Namenda treat ______. Name their MOAs and side effects
Aricept–Ach inhibitor
-diarrhea, headache
Namenda–NMDA antagonist
-fatigue
