Adrenal Drugs + Drugs for Anemia Flashcards
Adrenal UNDERsecretion, AKA _________ disease, signs include:
Addison’s (spongebob worm grandpa)
-low Na, High K
-Low glucose
-dehydration
-weight loss
Adrenal OVERsecretion, AKA ________ disease, signs include:
Cushing’s–werewolf
-moon face
-humpback
-hirsutism
-ecchymosis
-hypertension
-low K and high Na
-muscle atrophy
-glucose intolerance
Glucocorticoids (Corticosteriods) MOA
modify enzyme activity to control inflammatory response
Corticosteriods are used to treat adrenal _________, but not _________
-undersecretion (Addison’s)
-not oversecretion (Cushing’s)
Corticosteroid considerations/SFX
-werewolf SFX (moon face, hirsutism, weight gain/muscle wasting)
-monitor for electrolyte imbalances, hyperglycemia
-can impact mood
-give at same time each day w. food/milk
-rinse if inhaling
Methylprednisolone is the only ______-_______ corticosteroid
long-acting
The adrenal ______ secretes corticosteroids
cortex
Causes of anemia
-Maturation defects (iron/B12/folic acid deficiency, thalassemia)
-Hemolytic–RBC lysis (sickle cell, extrinsic factors)
“-poetins” for anemia would be given in what types of anemia? What’s a big side effect?
chemo, renal disease–need functioning bone marrow and iron
SFX: uncontrolled hypertension
“-stim” anemia drugs (fligrastim, pegfilgrastim) MOA, serious side effects
-MOA: neutrophil stimulators
-SFX: splenic rupture, hypersensitivity, bone pain
Iron for iron-deficient anemia: SFX, considerations
-GI issues, abdominal cramps, iron toxicity
-can turn feces tarry, liquid iron supplements can stain teeth
Folic acid is a _____-soluble vitamin essential for _______
-water
-erythropoiesis
Iron ______ is not commonly used because of the risk for anaphylaxis?
-dextran
Pegfilgrastim is a ________-_______ anemia drug, often given 1x after ______.
-long-acting
-chemo
antacids, milk, and other food (should/shouldn’t) be taken at the same time as iron
Should NOT, decreases absorption
