Anatomy and Physiology Flashcards
Locus Ceruleus (pons)
Norepinephrine
Ventral tegmentum and SNc (midbrain)
Dopamine
Raphe nucleus (pons, medulla, midbrain)
5-HT
Basal Nucleus of Meynert
ACh
Nucleus Accumbens
GABA
Anxiety NTs
Increased NE
Decreased 5-HT & GABA
Depression NTs
Decreased in NE, DA, 5-HT
Huntington NTs
Increased in DA
Decreased in ACh and GABA
Parkinson NTs
Increased in 5-HT, ACh
Decreased in Dopamine
Alzheimer NTs
Decreased in ACh
Nucleus accumbens and septal nucleus
Reward center, pleasure, addiction, fear
3 Structures in BBB
Tight Junctions b/w nonfenestrated capillary endothelial cells, basement membrane, astrocyte foot processes
Area Postrema
Vomiting after chemo
OVLT
osmotic sensing
Lateral Area of Hypothalamus
Hunger
Destruction = Anorexia, failure to thrive
Ventromedial Area of Hypothalamus
Satiety
Destruction = hyperphagia
Anterior Hypothalamus
Cooling, parasympathetic
Destruction = can’t cool down, too hot
Posterior Hypothalamus
Heating, Sympathetic
Destruction = can’t heat up, too cold
Suprachiasmatic Nucleus
Circadian Rhythm
Tx of bedwetting
oral desmopressin acetate (DDAVP)
Alcohol, Benzodiazepines and barbituates effect on sleep
decreases REM and delta wave
Extraocular movements during REM sleep
PPRF - paramedian pontine reticular formation
Awake eyes open
Beta, highest frequency, lowest amplitude
Awake eyes closed
Alpha
Stage N1
Light sleep, theta waves
Stage N2
Deeper sleep; when bruxism occurs
Sleep Spindles and K complexes
Stage N2
Stage N3
Deepest non-REM sleep; sleepwalking, night terrors, and bedwetting
Delta Waves
Lowest frequency, highest amplitude, Stage N3
REM sleep
Beta waves, Loss of motor tone, increased brain oxygen use and increased pulse and BP
Supraoptic Nuclei
ADH
Paraventricular Nuclei
Oxytocin
VPL Nucleus of Thalamus
Pain and temperature; pressure, touch, vibration, and proprioception
VPM Nucleus of Thalamus
Face sensation and taste
LGN Nucleus of Thalamus
From CN II, Vision (Lateral, light)
MGN Nucleus of Thalamus
From Superior olive and Inferior colliculus of tectum
Hearing (Medial, music)
VL Nucleus of Thalamus
From Basal Ganglia; motor
Limbic System Structures
Hippocampus, Amygdala, Fornix, Mammillary Bodies, and Cingulate Gyrus
Lateral Lesions of Cerebellum
propensity to fall toward injured (IL) side
Medial Lesions of Cerebellum
Vermal Cx, Fastigal nuclei and/or flocculonodular lobe
truncal ataxia, nystagmus, and head tilting
Wide-based cerebellar gait