Anat Final Endocrine + Sensory Flashcards
What is the endocrine system
Group of glands that produce hormones
- works w nervous system to control and coordinate other body systems
Chemical messengers that have specific regulatory effects on target cells within organs
Hormones
Hormones are released from
Endocrine glands into blood (ductless)
Hormones are very important for
Growth
metabolism
Reproduction
Behaviour
What are the hormones affecting many tissues
Growth hormone
Thyroid hormone
Insulin
What are hormones affecting a specific site
Thyroid stimulating hormone (TSH)
Adrenocorticotropic hormone (ACTH)
What are the 2 categories of hormones
Amino acid compounds
Lipids
Amino acids compounds consist of
Proteins
Amino acid compounds are _____ hormones; bind to receptors on target cell membrane triggering a 2nd messenger to affect cell activities
Non steroid
Lipids are made of ____
Lipids are ___ hormones; produced by the _____ and ______
Fatty acids; steroid hormones; produced by the adrenal cortex and sex glands
Example of steroid hormones (lipids)
Testosterone
progesterone
What are tightly regulated by homeostatic feedback, rhythmic patterns (daily or monthly) and other hormones
Blood levels are tightly regulated
Negative feedback is an action that causes
A 2nd action that stops the first action
(Most common)
Positive feedback
Hormone response produces more hormone
The pituitary gland “hypophysis” is divided into
Anterior and posterior lobes
In the anterior (adenohypophysis) lobe the hypothalamus sends
Releasing hormones and inhibiting hormones
In the posterior (neurohypophysis) lobe hormones are not
Produced here they are stored (ADH and oxytocin)
Hormones of the posterior lobe
Antidiuretic hormone (ADH)
Oxytocin
Antidiuretic hormone promotes what and stimulates what?
-Promotes the reabsorption of water from kidney tubules
-Stimulates construction of blood vessels
Oxytocin causes
Uterine contractions and trigger milk release from the breasts
Hormones of the anterior lobe(6)
- Growth hormone
- Thyroid stimulating hormone
- Adrenocorticotropic (ACTH)
- Prolactin
- Follicle stimulating hormone
- Luteinizing hormone
Gigantism refers to excessive growth due to
Over secretion of growth hormone in childhood
Acromegaly is a condition caused by oversecretion of
Growth hormone in adults
The thyroid gland is the largest endocrine gland and produces 2 hormones that increase metabolism which are
Thyroxine (T4)
Triiodothyronine (T3)
Thyroid gland disorders: goiters
Enlargement of thyroid gland
Thyroiditis
Inflammation of thyroid
Hypothyroidism can occur at multiple stages of life for multiple reasons. 3 disorders are
Endemic goiter (lack of iodine in diet)
Congenital (@birth)
Hashimoto thyroiditis (autoimmune)
Hyperthyroidism is an overactive thyroid; what disorders are associated
Graves’ disease (inherited- bulging eyes)
Thyroid storm
There are 4 parathyroid glands located where?
What do they secrete ?
Behind thyroid gland embedded in its capsule or surrounding CT
-secretes parathyroid hormone
Parathyroid hormone increases
Blood calcium levels
Parathyroid hormone is produced when
Blood calcium is low
Parathyroid hormone stimulates the production of
Calcitriol
Hyposecretion- inadequate production of PTH results in low blood calcium concentration and is associated with
Tetany- series of muscle contractions
Adrenal glands are located above the kidneys. Each gland has two separate parts acting as separate glands. What are they
Medulla- inner area
Cortex- outer area
In the adrenal medulla, epinephrine is the main hormone. It is released in response to
Sympathetic nervous system
“Fight or flight” response
(Increased bp, heart rate)
What are the 3 groups of hormones from the adrenal cortex
Glucocorticoids
Mineralocorticoids
Androgens
Major hormone of glucocorticoids is
Cortisol
(Secretion of glucocorticoid quickly increases when body is thrown into a condition of stress)
What is the major hormone of moneralocorticoid group
Aldosterone
(Regulated electrolyte balances)
Virilization refers to
Appearance of male characteristics facial hair and premature balding
Androgens deal with
Make sex hormones
Disorders of adrenal cortex: Addison’s disease
Hypofunction of adrenal cortex; insufficient amount of hormones
-muscle atrophy/weakness, skin pigmentation, and disturbances in salt/water balance
Disorders of adrenal cortex: cushings a syndrome
Hypersecretion of cortisol
(Obesity, thin skin, muscle weakness, bone loss high blood sugar, high BP)
-women may experience virilization
The pancreas has 2 types of cells
Acini
Pancreatic islets
Acini is ____
Secretes ______ through ducts into small intestine
Exocrine
Digestive enzymes
Pancreatic islets are ____
Produce hormones one being?
Endocrine
Insulin
Glucagon (pancreas hormone) is produced by ____ cells in response to
Alpha cells; in response to low blood glucose levels
What is the most common endocrine disorder and what is it
Diabetes mellitus
Insulin deficiency
Hyperglycaemia
Too much glucose in the blood
Hyperlipidemia
High blood levels of fat (cholesterol)
Ketoacidosis
Ketones in blood
(Acidic)
(Confusion, coma, death)
What are the two types of diabetes mellitus
-Insulin dependent diabetes mellitus
-Non insulin dependant diabetes mellitus
Insulin dependant diabetes mellitus is known as?
What does it result from?
Type 1 diabetes (formerly known as leveled diabetes)
Results from hyposecretion of insulin
LESS COMMON BUT MORE SEVERE
Non insulin dependant diabetes mellitus is known as
It is characterized by
Type II diabetes
Characterized by insulin resistance
Gestational diabetes is
Diabetes that develops during pregnancy
(Typically disappears after childbirth)
What is key to managing all diabetes
Maintaining Stable blood glucose levels by diet and exercise
Uncontrolled diabetes is associated with many long term complications including (4)
Abnormal fat metabolism
Damage to arteries
Damage to peripheral nerves
Decreased tissue repair
Management of type 1 diabetes
Insulin injections
Monitor blood sugar levels frequently
Management of type II diabetes
Monitor diet
Exercise
Oral medications “metformin”