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Antibiotics > Aminoglycosides > Flashcards

Aminoglycosides Flashcards

1
Q

Examples

A

Gentamicin

Tobramycin

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2
Q

MoA

A 
30s subunit of bacterial ribosome
Antagonist
Interfere with initiation complex of peptide formation
Induce mis-reading of mRNA
Break up polysomes (ribosome clusters)
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3
Q

Indications

A 
Gram negative sepsis w/ Penicillin (SYNERGY)
Pseudomonas
UTI
Sepsis
Pneumonia
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4
Q

ADR

A

Irreversibly ototoxicity

Reversible nephrotoxicity

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5
Q

Prescribing Advice

A

Decrease in Renal disease
Caution w/ diuretics, NSAIDs
Monitor serum trough + peak levels
IV or SC

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Antibiotics (13 decks)

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