Nitrofuran Antibiotics Flashcards
1
Q
Examples
A
Nitrofurantoin
2
Q
MoA
A
Poorly understood
Inhibit a number of bacterial enzymes including those involved in protein synthesis
DNA toxic
3
Q
Indications
A
UTIs (not if pseudomonal or proteus)
4
Q
ADR
A
GI upset Peripheral neuropathy Pulmonary fibrosis Hypersensitivity reactions (Skin + BM) Haemolytic anaemia
5
Q
Prescribing Advice
A
X Septicaemic (poor serum levels) X Renal Impairment (less effective + increased risk peripheral neuropathy) Caution in: Anaemia Diabetes mellitus Vitamin B12 and folate deficiency Pulmonary disease Hepatic and renal impairment Any condition associated with peripheral neuropathy (severe and irreversible neuronal damage may result)
