aldosterone antagonist

Question 1

What are side effects?

Answer 1

hyperkalaemia, which can lead to muscle weakness, arrhythmias, and even cardiac arrest.

Spironolactone causes gynaecomastia (enlargement of male breast tissue), which can have a significant impact on adherence in men (see COMMUNICATION). Eplerenone is less likely to cause endocrine side effects.
Aldosterone antagonists can cause liver impairment and jaundice and spironolactone is a cause of Stevens–Johnson syndrome (a T-cell-mediated hypersensitivity reaction) that causes a bullous skin eruption.

Question 2

What is the ONLY indication of Eplerenone?

Answer 2

Adjunct in stable patients with reduced ejection fraction or MI

chronic mild HF

Question 3

What are important interactions of aldosterone antagonist?

Answer 3

Manufacturer advises max. dose 25 mg daily with concurrent use of amiodarone or moderate inhibitors of CYP3A4

Question 4

what are indications of sprinolactone?

Answer 4

Oedema
Ascites in cirrhosis
Resistant HTN
Hyperaldosteronism in patients awaiting surgery