Acid-Base Balamce In The Body Flashcards
What is a major homeostatic challenge?
Keeping hydrogen levels of body in the appropriate range.
What type of diet produce more acid than bases and tend to acidify the blood?
High protein diet
What is the pH of systemic arterial blood?
7.35 and 7.45
What three major mechanisms that regulates removal of hydrogen?
Buffer systems
Exhalation of carbon dioxide
Kidney excretion of hydrogen into the urine
What substances act quickly to temporarily bind H+, removing the highly reactive, excess H+ from solution but not from the body?
Buffers
What buffer systems maintain pH?
Protein buffer system
Carbonic acid-bicarbonate buffer system
Phosphate buffer system
What is the most abundant buffer in ICF and Plasma?
Proteins
What does the carboxyl group work on?
Releases hydrogen when pH rises and reacts with excess OH-.
Can proteins buffer both acids and bases?
Yes
HCO3 acts as what?
Weak base
H2CO3 acts as what?
Weak acid
Where are the concentrations of phosphates highest in?
ICF which makes them an important buffer in the cytosol
At what range is arterial blood considered acidosis?
Less than 7.35 and under 7 is fatal
At what range is arterial blood considered alkalosis?
Greater than 7.45 which leads to muscle spasm