A23 - Tumor-induced angiogenesis (capillary incorporation, budding of endothelial cells)

Question 1

What is the tumour induced angiogenesis called?

Answer 1

Neoangiogenesis

= Formation of new blood vessels

Question 2

Why is neoangionesesis important for a tumour?

Answer 2

The tumour cannot grow bigger without it. At 1-2cm the tumour will still recivede oxgen and nutrition from the surrounding healthy cells and tissue, but above this size the tumour needs its own vascular system

No neoangiogenesis = No metastasis

The newly formed vessels are abnormal, they will be permeable and dilated giving the tumour a higher chance for metastasis

Question 3

Name the types of neoangiogenesis:

Answer 3

2 types

1. Neovascularisation

2. Vasculogenesis

Question 4

What is Neovascularisation?

Answer 4

New vessels budding from the already existing capillaries in the tumour

Question 5

What is Vasculogenesis?

Answer 5

Bone marrow derived endothelial cells migrating into the tumour and the will form a new vascular network

Question 6

Name some antiangiogenetic factors

Answer 6

angiostatin, endostatin and vasculosatin

They are produced by the body, but can also be used as a mode of therapy