A14 - Infiltrative processes during acute inflammation Flashcards
What is meant by infiltrative process?
It is different cells infiltrating the site of injury/inflammation within the first 24-48 hours
What happens during the infiltration during an acute inflammation?
The neutophils will travel to the site injury/action, via the blood vessels, during this “journey” the neutrophils will undergo MAEC
The neutrophils will infiltrate during the first 24-48 hours, then they will be replaced by the monocytes and macrophages
What is MAEC?
Margination
Adhesion
Emigration
Chemotaxis
What is Margination?
The cells will line up against the endothelium
What is adhesion?
The cells connect to the epithelial wall
What is emigration?
The leukocytes move along the wall to find the affected area
What is chemotaxis?
Once the leukocytes reach the area, they will undergo extravasation and go to the extravascular space and go to the affected site
What happens to the neutrophils, once they are at the right place and recognise the foreign body?
They will start phagocytosis
Phagocytosis is the major role of neutrophils
what is phagocytosis?
It is the process where the foreign body/pathogen is engulfed/encapsuled and contained with a phagosome, which then is destroyed via either oxygen-dependent og oxygen-independeent degradation
What is oxygen dependent degradation of phagosome?
Dependent on the presence of oxygen and the generation of reactive oxygen and the generation of reactive oxygen species
What is oxygen INdependent degradation of phagosome?
Not dependent on oxygen, uses preformed granules containing proteolytic enzymes to kill microbes
