A- 7. ACE-inhibitors, angiotensin-receptor antagonists, vasodilators

Question 1

ACE inhibitors drugs

Answer 1

Benazepril
Ramipril
Lizinopril (liver safe)

Question 2

Angiotensin receptor antagonists drugs

Answer 2

telmisartan

Question 3

Calcium channel blocker

Answer 3

Diltiazem

Question 4

ACE inhibitors mechanism of action

Answer 4

stops angiotensin converstase to convert Ang I to AngIII

Question 5

ACE inhibitors effects

Answer 5

decrease after load (vasodilation)
decrease preload ( Venodilation & increase Na + H20 excretion)

Question 6

ACE inhibitors indication

Answer 6

Heart failure
Hypertension (fe)
Kidney failure (ca)
Feline CKD to lower proteinuria

Question 7

PK of ACE inhibitors

Answer 7

PO
activated in liver (except Lizinopril)

Question 8

Side effects of ACE inhibitors

Answer 8

Hypotension
diarrhea
dry cough
vomiting
azotemia
dehydration

Question 9

Benazepril

Answer 9

excreted by bile
good for kidney patients

Question 10

ACE inhibitors for liver patients

Answer 10

Lizinapril

Question 11

ACE inhibitors for kidney patients

Answer 11

Benazepril

Question 12

indication for angiotensin receptor

Answer 12

more effective
no bradykinin activation (cough stimulation)

Question 13

ACE inhibitors for horses

Answer 13

quinapril

Question 14

vasodilatation drugs

Answer 14

Organic nitrates (nitroglycerin)
Ca channel blockers (amlodipine, verapamil & diltiazem)

Question 15

nitroglycerin

Answer 15

pronounced dilation
first pass effect = transdermal patch, IV, sublingual
to decompensated heart failure

Question 16

action of ca channel blockers on the heart

Answer 16

verapamil > diltizem > amlodipine

Question 17

Amlodipine

Answer 17

PO
hypertension in cats

Question 18

Verapamil & diltiazem

Answer 18

negative inotropic = not for HF

Question 19

other substances for vasodilation

Answer 19

alpha 1 antagonists:
- prazosin
- doxasozin