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Pharma Final > A-3. Opioids > Flashcards

A-3. Opioids Flashcards

1
Q

Must know drugs opioids

A
  • Morphine
  • Fentanyl
  • Tramadol
  • Butorphenol
  • Buprenorphine
  • Naloxone
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2
Q

G effects of opioids

A

Analgesia, sedation, euphoria, cough relief & antidiarrheal

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3
Q

side effects of opioids

A
  • resp dep
  • emesis
  • bradychardia
  • obstipation
  • histamine release (morphine)
  • hyperthermia
  • excitation & dysphoria (fe)
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4
Q

most imp side effects of opioids

A

Respiratory depression

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5
Q

analgesic effect of u opioid R

A

specific, strong analgesic (pre & post synaptic)
slight sedation & antitussive

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6
Q

analgesic effect of K opioid R

A

only pre synaptic
slight analgesic & sedation effect
(responsible for the dysphoria)

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7
Q

analgesic effect of D opioid R

A

analgesia (most imp in the eye)

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8
Q

full agonist of mu R

A

-morphine
- fentanyl
- tramadol

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9
Q

full antagonist of mu & K R

A

Naloxone

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10
Q

partial agonist of mu R

A

Buprenorphine

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11
Q

Agonist (K) & Antagonist (u)

A

Butorphanol

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12
Q

morphine side effects & administration

A

sedation, Resp Dep, bradycardia & emesis
slow IV, IM

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13
Q

Fentanyl side effects & administration

A

sedation, Resp Dep, bradycardia
transdermal patch

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14
Q

tramadol side effects & administration

A

NO glucuronidation –> longer effect in cats
analgesic & cough relief

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15
Q

Buprenorphine effects

A

ceiling effect, slight sedation & analgesia
(resp dep)

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16
Q

Butorphanol

A

slight analgesic, Visceral analgesia
(sedation, cough relief & light resp dep)
very safe: agonist-antagonist

17
Q

metabolism of morphine

A

liver: morphine glucuronide (danger in Fe)

18
Q

fentanyl DOA

A

transdermal: 2-3 min
perfusion: onset: 1-2min & DOA: 15-20min

19
Q

Morphine DOA

A

Onset: 30 min
DOA: 4-6hours

20
Q

Tramadol DOA

A

3-8h

21
Q

Buprenorphine DOA

A

6-12h

22
Q

Butorphenol DOA

A

3-4h

Pharma Final (15 decks)

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