A-5. Injectable anaesthetics Flashcards
COMBINATIONS USED FOR NEUROLEPTANALGESIA
Etorphine & Acepromazine (large & smalls)
Butorphanol & Acepromazine (ca &eq)
Fentanyl & Fluanisone (rodent)
Fentanyl & Droperidol (dog)
COMBINATIONS INTENDED FOR LIGHT PLANE ANAESTHESIA
Xylazine with:
- ketamine, butorphanol & telazol
medetomidine with:
- ketamine, telazol, butorphanol & propofol
Azaperone & metomidate ( swine only)
injectable anaesthetics drugs
pentobarbital & thiopental
propofol
ketamine
tiletamine
ideal properties of injectable anaesthetics
water & lipid soluble
sufficiently potent
muscle relaxant
non irritant
rapid & safe induction/ recovery
limited effect on vital function
high TI
not hepato/nephro toxic
rapid metabolism
antagonist available
no chemical / Pharma incompatibility
Barbiturates mechanism of action
increase GABA activity
Barbiturates short and ultrashort DOA
short: 15-60min
U-short: 5-8min
effects of Barbiturates
muscle relaxant, unconsciousness
Side effects of Barbiturates
Cardio & Resp dep
tissue irritation
Pre & post narcotic excitation
Pk of Barbiturates
accumulation in adipose tissue
Quick & complete distribution (ok BBB)
Pentobarbital as injectable anaesthetic
slow induction, strong excitement
small ruminants metabolize faster
thiopental as injectable anaesthetics
standard drug for induction (not maintenance)
but tissue irritant
propofol
Unconsciousness, MM
not tissue irritant, slowly given IV
quick & complete distribution
for induction, TIVA + analgesic, epilepsy
imidazole drug used as injectable anaesthetics
etomidate
etomidate
safest fo cardioV patients
SE:
- mild Resp Dep, Pre&Post narco exci
what are the dissociative anaesthetics
Ketamine & Tiletamine
