A-1: Neuroleptics Flashcards
Give the 2 main groups of tranquilizers
Phenothiazine & Butyrophenone
Must know drugs of major tranquilizers
Phenothiazines : Acepromazine, Chlorpromazine
Butyrophenone: Azaperone
G effect of tranquilizers
Inhibit the CNS
Use of phenothiazines
Calming
sedation (aggressive animals)
Pre-Med (potentiates analgesics)
PK of phenothiazines
Poor oral abs (used IV,IM)
Slow onset
Administration method of phenothiazines
IV, IM
Butyrophenone action
More potent than phenothiazines
SLIGHT analgesic effects
Which drug is used to induce neuroleptanalgesia
Droperidol
Indication of Butyrophenone
Sedation for swine
Azaperone administration
NEVER IV, only IM
Effects of tranquilizers
Decrease of :
Motor activity
Response to stimuli of fear
NO (mild for Butyrophenone) analgesia but potentiate
Increase of dose of tranquilizers
Increase length of sedation (not elevating effect)
Indications of tranquilizers
Sedation
Antiemetic
Preanaesthesia
Neuroleptanalgesia
Allergy (has anti histamine effect)
Side effects of tranquilizers
Hypotension
Tissue irritation
Epileptic seizure
Lack of thermorégulation
Pseudopregnancy
Penile prolapse
3rd eyelid prolapse
Contraindication of tranquilizers
Dehydrated patients
Boxers & bull dogs
Diabetic patients
Epileptic patients
