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pharma final > A-22. Phenicols, lincosamides and pleuromutilins > Flashcards

A-22. Phenicols, lincosamides and pleuromutilins Flashcards

1
Q

Phenicols drugs

A

Chloramphenicol
Florfenicol

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2
Q

Lincosamides

A

Lincomycin
clindamycin

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3
Q

pleuromutilins

A

tiamulin
valnemulin

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4
Q

MA of lincosamides

A

inhibition of prot synthesis : 50S
Bacteriostatic

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5
Q

PK of lincosamides

A

A: good
D: Good (not BBB)
M: Liver
E: Bile & urine

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6
Q

combination with lincomycin

A

Spectinomycin = lincospectin

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7
Q

indication of lincomycin

A

FPA
foot rot, wounds, mastitis, swine dysentery, proliferative enteropathy, mycoplasmosis

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8
Q

indication of clindomycin

A

small
dermatitis
abscess
oral cav inf
anal sacculitis

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9
Q

SE of lincosamides

A

tissue irritation
dysbacteriosis

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10
Q

spectrum of lincosamides

A

NOT fastidious Gr-
gram +
Gr- anaerobic
B. hyodysenteriae
L. intracellularis
Mycoplasmae
campylobacter

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11
Q

lincosamides first choice for

A

osteomyelitis & bone surgery

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12
Q

MA of pleuromutilins

A

inhibition of prot synthesis : 50S
Bacteriostatic

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13
Q

PK of pleuromutilins

A

A: Good
D: Good (not BBB)
M: Liver (enzyme inhibitor CYP450)
E: bile & urine

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14
Q

Side effects of pleuromutilins

A

skin erythema
vulvar edema

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15
Q

spectrum of pleuromutilins

A

fastidious gr-
B. hyodysenteria
L. intracellularis
mycoplasma

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16
Q

indication of pleuromutilins

A

swine dysentery,
proliferative enteropathy
mycoplasma
RI

17
Q

structure of phenicols

A

lipophilic small molecules
NOO- in chloramphenicol causes hypersensitivity in humans

18
Q

MA of phenicols

A

inhibition of 50S
bacteriostatic

19
Q

spectrum of phenicols

A

gr +
gr - (similar to TC)
mycoplasmae
NOT P. aeruginosa

20
Q

PK of phenicols

A

A: excellent (good eye)
D: excellent (ok BBB)
M: liver (not for liver patients)
E: bile & urine (inactive)

21
Q

half life of phenicols according to species

A

Ru (2days)
Sus (SID)
Fe (BID)
Ca (TID)

22
Q

Side effects of phenicols

A

anaemia
immunosuppresion

23
Q

indication of florphenicol

A

FPA
RI (mycoplasma & fastidious Gr-)
Foot disease
infectious KC
fish aeromonas inf

24
Q

indications of phenicols for smalls

A

eye inf
prostatitis
meningitis
MRSA &MRSP

25
Q

Ameg of phenicols

A

C

pharma final (15 decks)

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