A-22. Phenicols, lincosamides and pleuromutilins Flashcards
Phenicols drugs
Chloramphenicol
Florfenicol
Lincosamides
Lincomycin
clindamycin
pleuromutilins
tiamulin
valnemulin
MA of lincosamides
inhibition of prot synthesis : 50S
Bacteriostatic
PK of lincosamides
A: good
D: Good (not BBB)
M: Liver
E: Bile & urine
combination with lincomycin
Spectinomycin = lincospectin
indication of lincomycin
FPA
foot rot, wounds, mastitis, swine dysentery, proliferative enteropathy, mycoplasmosis
indication of clindomycin
small
dermatitis
abscess
oral cav inf
anal sacculitis
SE of lincosamides
tissue irritation
dysbacteriosis
spectrum of lincosamides
NOT fastidious Gr-
gram +
Gr- anaerobic
B. hyodysenteriae
L. intracellularis
Mycoplasmae
campylobacter
lincosamides first choice for
osteomyelitis & bone surgery
MA of pleuromutilins
inhibition of prot synthesis : 50S
Bacteriostatic
PK of pleuromutilins
A: Good
D: Good (not BBB)
M: Liver (enzyme inhibitor CYP450)
E: bile & urine
Side effects of pleuromutilins
skin erythema
vulvar edema
spectrum of pleuromutilins
fastidious gr-
B. hyodysenteria
L. intracellularis
mycoplasma
indication of pleuromutilins
swine dysentery,
proliferative enteropathy
mycoplasma
RI
structure of phenicols
lipophilic small molecules
NOO- in chloramphenicol causes hypersensitivity in humans
MA of phenicols
inhibition of 50S
bacteriostatic
spectrum of phenicols
gr +
gr - (similar to TC)
mycoplasmae
NOT P. aeruginosa
PK of phenicols
A: excellent (good eye)
D: excellent (ok BBB)
M: liver (not for liver patients)
E: bile & urine (inactive)
half life of phenicols according to species
Ru (2days)
Sus (SID)
Fe (BID)
Ca (TID)
Side effects of phenicols
anaemia
immunosuppresion
indication of florphenicol
FPA
RI (mycoplasma & fastidious Gr-)
Foot disease
infectious KC
fish aeromonas inf
indications of phenicols for smalls
eye inf
prostatitis
meningitis
MRSA &MRSP
Ameg of phenicols
C
