9.5.3: Acute diarrhoea Flashcards
Causes of acute diarrhoea
- Diet: acute gastroenteritis e.g. allergy, intolerance, scavenging, toxins
- Drugs: antimicrobials, chemo
- Infectious: viral, bacterial, parasitic
- Inflammatory disease: CE/IBD, pancreatitis
- Metabolic disease: hypoadrenocorticism
- Anatomic disease: intussusception / FB
- Neoplasia: peracute lymphoma, paraneoplasia
- Anomalous: stress/ anxiety - usually mixed/large bowel
Which animals would you particularly expect infectious diarrhoea in?
- Young animals / immunocompromised
- Animals in colonies / kennels
- Mixed infections e.g. parasites + viruses will be worse. Often worms are the complicating factor and treating worms makes the other disease more manageable.
- Seen less in vaccinated, healthy animals
Viruses that cause acute infectious diarrhoea
- Parvovirus
- Coronavirus
- Adenovirus
- FeLV, FIV - chronic enteritis, weight loss, lymphoma in FeLV
- Rotavirus
- (Norovirus)
Bacteria that cause acute infectious diarrhoea
- Salmonella
- Campylobacter
- E. coli - ETEC, EHEC, EPEC
- Clostridium perfringens, Clostridium difficile
- Shigella
- Yersinia enterocolitica - rarely reported
Parasites that cause acute infectious diarrhoea
- Helminths
- Protozoa e.g. Giardia, Tritrichomonas
Clinical signs of parvovirus infection
- Vomiting
- Haemorrhagic diarrhoea: profuse and foetid, with mucosal sloughing
- Rapid dehydration
- Panleucopaenia
- Depression
- Anorexia
- Pyrexic
- Loss of mucosal barrier -> septicaemia / endotoxaemia and shock / DIC
- Ileus
Signalment for parvovirus
- Young puppies with low maternal immunity (pre-vaccination)
- Older unvaccinated dogs (breed predisposition - black and tan?)
Causative agent of parvovirus and characteristics
Canine parvovirus 2 (CPV-2)
* Virus stable in environment for years
* Faeco-oral - 3-6 days incubation
Differential diagnoses for parvovirus
- HGE including neoplasia and idiopathic HGE (AHDS)
- Salmonella, enteric infection
- Intussusception
- FB
- Hypoadrenocorticism
- Acute intoxication: e.g. spoilt food
AHDS
Acute haemorrhagic diarrhoea syndrome
Diagnosis of parvovirus
- Signalment and clinical signs highly suggestive
- Faecal analysis: antigen SNAP - severe necrosis of GIT may lead to false -ves
- Haematology and biochemistry - consequences of disease - panleucopaenia; azotaemia, acid-base disturbance, electrolyte disturbances, liver enzymes abnormal, possibly low TP
Management of parvovirus
- Aggressive fluid therapy; assess acid-base status in case severe imbalance - may need to consider colloid/ plasma/ whole blood
- Antibiotics: broad spectrum (amox/clav ± quinolone), take care re age of patient; gram -ve coverage difficult in young animals
- Anti-emetics (aggressively!!) e.g. maropitant, metoclopramide due to marked nausea
- Pro-motility medications e.g. metoclopramide as enteritis decreases motility
- Antacids and ulcer coating medication - severe gastritis can develop along with reflux oesophagitis and strictures
- Begin oral fluid/ nutients ASAP; may require assistance e.g. NO tube
Prevention of parvovirus
- Vaccination + do not take puppies out too early!
- Cleaning and disinfection: bleach/ Virkon
Pathogenesis, signalment and clinical signs of haemorrhagic gastroenteritis
Syndrome of acute haemorrhagic diarrhoea (AHDS)
* Idiopathic in most cases; may be Type I hypersensitivity reaction or C. perfringens enterotoxin production
* Usually small breed dogs
Clinical signs
* Vomiting ± blood
* Foetid diarrhoea including protein loss - brown water
* Depression, anorexia - very ill
* Haemoconcentration (fluid shift into GIT means hypovolaemia before clinical dehydration apparent)
Differential diagnoses for haemorrhagic gastroenteritis and how you could differentiate between them
Ddx for HGE:
* Parvoviral enteritis - HGE will not show leucopaenia but parvo will
* Intussusception
* Pancreatitis
Treatment and prognosis of HGE
Treatment
* Aggressive fluid therapy - same as parvo; colloid/ plasma/ whole blood depends on degree of haemorrhage and complications
* Antimicrobial - only if signs of sepsis: amox/clav + metronidazole + fluoroquinolone
Prognosis
* Good in most cases
* If TP low and systemic inflammatory response = guarded
Pathogenesis of feline panleucopaenia
- Feline panleucopaenia virus (basically feline parvo; cats can also be infected by canine parvovirus)
- Kittens/ colonies often affected, virus widespread in feral cats
- Transmission and signs the same as canine parvovirus
- Also: repro failure / cerebellar hypoplasia (infections in utero)
Signalment, clinical signs and treatment of coronavirus infection in dogs
Signalment
* Young dogs (pos age-related immunity)
* Highly contagious
Clinical signs
Mild villus destruction - enterocytes at tips
* Usually subclinical but strain-related and co-infection can worsen disease
* Predominantly small bowel diarrhoea
* If severe, may see vomiting and watery/ mucoid diarrhoea
Treatment
* Supportive IVFT
* Nutritional support for GIT