23.11.3: Scale disease Flashcards
For more detail on treatments, see specific lecture notes ('Scale disease - 1/3/2023'). Details of different moisturisers not included here.
What is scale and what does it result from?
Scale: presence of flakes of keratin in the hair coat and on the skin. Scale may be adherent (well attached to the epidermis) or loosely attached.
Scale results from:
* Normal skin function (a little scale a.k.a. dandruff = normal in many situations)
* Abnormal desquamation (shedding of corneocytes)
* Abnormal cornification (creation of the outer epidermal layers)
* Inflammation (inflammation induces cell turnover)
* Bacterial and fungal enzymatic action
Diseases in which scale is noted
1
Diseases in which scale is noted
2
Which is more common: primary or secondary scale?
Secondary scale is very much more common than primary disease.
Diagnostic plan for animal presented with scaling disease
1-5
Signalment and presentation of Zinc-responsive dermatosis
Signalment
* Genetically predisposed breeds e.g. Huskies have Type I = genetic poor absorption of zinc
* Often young adult onset in winter
* Type II = nutritional restriction in young, rapidly growing large breeds
* Beware concurrent hypothyroidism (older animals, later onset)
Clinical presentation
* Dull coat and specific hard plaques with marked scale and crusting; lesions occur wherever dog knocks itself
* Crusted hyperkeratosis (bacterial infection common) -> lift crust and do cytology to check for infection
* ± Bacterial infection
* Variable pruritus, more so if infected
Zinc responsive dermatosis
Histological findings with zinc-responsive dermatosis
- Parakeratosis is a key finding
- Nuclei are retained in the stratum corneum; this is seen to a lesser extent in bacterial pyoderma and in superficial necrolytic dermatitis
- Zinc is required for normal keratinisation -> disease most common at areas of trauma
Treatment of zinc-responsive dermatosis
- Zinc supplementation - Zinc sulphate traditionally used but may cause vomiting
- Correct diet
- Consider steroids if Type I and poor response (hard to get enough zinc into a husky, a tiny amount of anti-inflammatory dose steroids help but we don’t know how)
History and clinical presentation of ichthyosis of Goldern Retrievers
- Seen from a few weeks old; scale variable over life but can be severe; need to rule out ectoparasites as a ddx
- Barrier function is not compromised -> secondary infection is uncommon, secondary otitis can occur
- Genetic disease, recessive allele -> genetic testing recommended
Treatment of ichthyosis of Golden Retrievers
- Symptomatic treatment only
- Manage with shampoos
- Vitamin A-like analogues (retinoids) used with some success but quite severe drugs
Signalment and clinical presentation of canine ear margin seborrhea
- Relatively uncommon
- Marked breed predilection in Dachshunds
- Can be a feature of hypothyroidism
- Adherent keratin on both medial and lateral sides of the pinna
- Follicular casts and plugs may trap hair
- Rubbing produces erosions and ulceration
- Pruritus is variable
- Fissuring and secondary infection can be problematic
Differential diagnoses for canine ear margin seborrhea
- Secondary causes of pinnal seborrhea
- Hypothyroidism
- Trauma due to pinnal flapping
- Early vasculitis
- Early localised scabies
Diagnosis and treatment of canine ear margin seborrhea
Important differential diagnoses for nasodigital hyperkeratosis
There are many possible ddx. Important ones:
* Superficial necrolytic dermatitis - would expect animal to be painful, systemically unwell, and more widespread disease
* Epitheliotropic cutaneous lymphoma - hypopigmentation, ulceration, progression beyond the nose and pads
* Demodicosis (foot pad disease) - rare, look for signs of mites elsewhere on the dog