23.11.3: Scale disease Flashcards

For more detail on treatments, see specific lecture notes ('Scale disease - 1/3/2023'). Details of different moisturisers not included here.

1
Q

What is scale and what does it result from?

A

Scale: presence of flakes of keratin in the hair coat and on the skin. Scale may be adherent (well attached to the epidermis) or loosely attached.

Scale results from:
* Normal skin function (a little scale a.k.a. dandruff = normal in many situations)
* Abnormal desquamation (shedding of corneocytes)
* Abnormal cornification (creation of the outer epidermal layers)
* Inflammation (inflammation induces cell turnover)
* Bacterial and fungal enzymatic action

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2
Q

Diseases in which scale is noted
1

A
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3
Q

Diseases in which scale is noted
2

A
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4
Q

Which is more common: primary or secondary scale?

A

Secondary scale is very much more common than primary disease.

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5
Q

Diagnostic plan for animal presented with scaling disease
1-5

A
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6
Q

Signalment and presentation of Zinc-responsive dermatosis

A

Signalment
* Genetically predisposed breeds e.g. Huskies have Type I = genetic poor absorption of zinc
* Often young adult onset in winter
* Type II = nutritional restriction in young, rapidly growing large breeds
* Beware concurrent hypothyroidism (older animals, later onset)

Clinical presentation
* Dull coat and specific hard plaques with marked scale and crusting; lesions occur wherever dog knocks itself
* Crusted hyperkeratosis (bacterial infection common) -> lift crust and do cytology to check for infection
* ± Bacterial infection
* Variable pruritus, more so if infected

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7
Q
A

Zinc responsive dermatosis

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8
Q

Histological findings with zinc-responsive dermatosis

A
  • Parakeratosis is a key finding
  • Nuclei are retained in the stratum corneum; this is seen to a lesser extent in bacterial pyoderma and in superficial necrolytic dermatitis
  • Zinc is required for normal keratinisation -> disease most common at areas of trauma
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9
Q

Treatment of zinc-responsive dermatosis

A
  • Zinc supplementation - Zinc sulphate traditionally used but may cause vomiting
  • Correct diet
  • Consider steroids if Type I and poor response (hard to get enough zinc into a husky, a tiny amount of anti-inflammatory dose steroids help but we don’t know how)
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10
Q

History and clinical presentation of ichthyosis of Goldern Retrievers

A
  • Seen from a few weeks old; scale variable over life but can be severe; need to rule out ectoparasites as a ddx
  • Barrier function is not compromised -> secondary infection is uncommon, secondary otitis can occur
  • Genetic disease, recessive allele -> genetic testing recommended
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11
Q

Treatment of ichthyosis of Golden Retrievers

A
  • Symptomatic treatment only
  • Manage with shampoos
  • Vitamin A-like analogues (retinoids) used with some success but quite severe drugs
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12
Q

Signalment and clinical presentation of canine ear margin seborrhea

A
  • Relatively uncommon
  • Marked breed predilection in Dachshunds
  • Can be a feature of hypothyroidism
  • Adherent keratin on both medial and lateral sides of the pinna
  • Follicular casts and plugs may trap hair
  • Rubbing produces erosions and ulceration
  • Pruritus is variable
  • Fissuring and secondary infection can be problematic
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13
Q

Differential diagnoses for canine ear margin seborrhea

A
  • Secondary causes of pinnal seborrhea
  • Hypothyroidism
  • Trauma due to pinnal flapping
  • Early vasculitis
  • Early localised scabies
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14
Q

Diagnosis and treatment of canine ear margin seborrhea

A
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15
Q

Important differential diagnoses for nasodigital hyperkeratosis

A

There are many possible ddx. Important ones:
* Superficial necrolytic dermatitis - would expect animal to be painful, systemically unwell, and more widespread disease
* Epitheliotropic cutaneous lymphoma - hypopigmentation, ulceration, progression beyond the nose and pads
* Demodicosis (foot pad disease) - rare, look for signs of mites elsewhere on the dog

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16
Q

Signalment of nasodigital hyperkeratosis

A

Nasodigital hyperkeratosis: broad term for dogs with non-iflamed, quiescent and tightly adherent hyperkeratosis affecting the nose and sometimes the feet.
* Usually older dogs
* No sex or breed predisposition
* Probably a senile change

17
Q

Clinical signs of nasodigital hyperkeratosis

A
  • Nasal lesions can be variable: frond-like projections or hard surface. Nose is dry, and cracks and fissures can occur and lead to irritation.
  • Pad lesions: all pads affected, and most prominent at edges due to weight bearing. Lack of flexibility of pad leads to cracking, formation of corns, lameness.
18
Q
A

Nasodigital hyperkeratosis

19
Q

Diagnosis of nasodigital hyperkeratosis

A
20
Q

Treatment of nasodigital hyperkeratosis

A
  • Cut off prominent fronds with scissors or scalpel blade
  • Hydrate the keratin using shampoos and soaks
  • Essential fatty acids PO
21
Q
A

Nasal parakeratosis of Labrador Retrievers

22
Q

History and clinical signs of Nasal parakeratosis of Labrador Retrievers

A
23
Q

Differential diagnoses, diagnosis and treatment of nasal parakeratosis of Labrador Retrievers

A
24
Q

History and clinical signs of footpad hyperkeratosis of Dogue de Bordeaux

A

There is popilteal and prescapular LN enlargement in cases of pedal infection (where the skin has split and enabled bacterial infection)

25
Q
A

Footpad hyperkeratosis of Dogue de Bordeaux

26
Q

Diagnosis and treatment of footpad hyperkeratosis of Dogue de Bordeaux

A
27
Q

Where are calluses typically formed? If they are found elsewhere, what might this tell you about your patient?

A
  • Often found over hocks, elbows, sternum, ischium
  • Callus = normal response to pressure-induced ischaemia and inflammation
  • Secondary infection is common
  • Other areas involved - may suggest orthopaedic problems or hypothyroidism
28
Q

Diagnosis and treatment of calluses

A

Diagnosis
* Typical clinical signs and position
* Can perform skin surface and exudate cytology -> bacterial cylture
* Can perform biopsy if needed for tissue culture

Treatment
* Treat secondary infection
* Remove trauma / pressure
* Consider bandaging and padding
* Surgery can help but need to consider if post-surgery the same factors that caused the callus will remain and lead to breakdown of the wound

29
Q

Signalment and clinical signs of thymoma-induced exfoliative dermatitis

A

This is a cutaneous marker of systemic disease.

30
Q

Diagnosis and treatment of thymoma induced exfoliative dermatitis

A
31
Q

You think you have diagnosed a dog with idiopathic canine sebaceous adenitis, but then you suddenly realise it has previously travelled abroad. What do you now need to consider?

A

Histological sebaceous adenitis can be seen in a variety of disease but particularly Leishmaniasis

32
Q

Pathogenesis of idiopathic sebaceous adenitis

A
33
Q

Clinical signs and diagnosis of idiopathic sebaceous adenitis

A
34
Q
A

Idiopathic canine sebaceous adenitis

35
Q

Treatment of idiopathic canine sebaceous adenitis

A
36
Q

2 major categories of treatment for scaling disease

A
37
Q

1 and 2

A