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MTAP 2 Hematology Part 1 > 9.1 Anemia (Microcytic) > Flashcards

9.1 Anemia (Microcytic) Flashcards

1
Q

Defined as a decrease in the oxygen-carrying capacity of the blood.

A

Anemia

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2
Q

The term anemia is derived from the Greek word anaimia, meaning “without blood”

T or F

A

T

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3
Q

Serum Iron: Decrease
TIBC: Increase
Transferrin saturation: Decrease
Serum ferritin: Decrease
FEP/ZPP: Increase
sTfR: Increase

a. Iron Deficiency Anemia
b. Anemia of Chronic Inflammation
c. Thalassemia
d. Sideroblastic anemia

A

a

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4
Q

Serum Iron: N
TIBC: N
Transferrin saturation: N
Serum ferritin: N
FEP/ZPP: N
sTfR: N

a. Iron Deficiency Anemia
b. Anemia of Chronic Inflammation
c. Thalassemia
d. Sideroblastic anemia

A

c

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5
Q

Serum Iron: Decrease
TIBC: Decrease
Transferrin saturation: Decrease
Serum ferritin: Increase
FEP/ZPP: Increase
sTfR: N

a. Iron Deficiency Anemia
b. Anemia of Chronic Inflammation
c. Thalassemia
d. Sideroblastic anemia

A

b

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6
Q

Serum Iron: Increase
TIBC: Decrease
Transferrin saturation: Increase
Serum ferritin: Increase
FEP/ZPP: Increase
sTfR: N

a. Iron Deficiency Anemia
b. Anemia of Chronic Inflammation
c. Thalassemia
d. Sideroblastic anemia

A

d

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7
Q

Inadequate intake; increased need, impaired absorption, chronic blood loss

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

a

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8
Q

In IDA

Acute blood loss = Normocytic anemia
Chronic = Microcytic

T or F

A

t

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9
Q

In IDA (Iron Depletion

Storage iron depletion

a. Stage 1
b. Stage 2
c. Stage 3

A

a

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10
Q

In IDA (Iron Depletion

Functional iron depletion

a. Stage 1
b. Stage 2
c. Stage 3

A

c

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11
Q

In IDA (Iron Depletion

Transport iron depletion

a. Stage 1
b. Stage 2
c. Stage 3

A

b

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12
Q

In IDA (Iron Depletion

When Stored iron is depleted, it is reflected by serum ferritin, resulting to a decreased serum ferritin level

a. Stage 1
b. Stage 2
c. Stage 3

A

a

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13
Q

In IDA (Iron Depletion

Reflected by a Decreased serum iron

a. Stage 1
b. Stage 2
c. Stage 3

A

b

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14
Q

In IDA (Iron Depletion

Reflected by low levels / decreased hemoglobin iron

a. Stage 1
b. Stage 2
c. Stage 3

A

c

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15
Q

Symptoms: Glossitis, pica, koilonychias

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

a

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16
Q

Rheumatoid arthiritis, chronic infections, and malignancies

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

b

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17
Q

Production of Acute-Phase Reactants - which inhibit iron utilization

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

b

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18
Q

Inhibits ferroportin whih promotes intestinal iron absorption and iron release

Increase during inflammation

a. Hepcidin
b. Lactoferrin

A

a

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19
Q

Competes with transferrin in binding iron

a. Hepcidin
b. Lactoferrin

A

b

20
Q

NOTE: in anemia of chronic inflammation:

  • increase of ferritin meaning more stored iron however, the presence of inhibitor prevents using this stored iron (Hepcidin) which is increased in chronic inflammation
A
21
Q

Reduced or absent synthesis of one or more globin chains of hemoglobin (Quantitative defect)

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

c

22
Q

Hemoglobin synthesized:
- Hemoglobin Bart’s
- Hemoglobin H

a. Alpha thalassemia
b. Beta thalassemia

A

a

23
Q

In Alpha Thalassemia, Hemoglobin synthesized:
- Hemoglobin Bart’s - Usually seen in newborns
- Hemoglobin H - Usually seen in adults

T or F

A

T

24
Q

In Alpha Thalassemia, Hemoglobin synthesized:

  • Hemoglobin Bart’s - 4 ________ globin
  • Hemoglobin H - 4 ________ Globin chains
A

Gamma

Beta

25
Q

Defective genes: 1 (-aa/a)

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

a

26
Q

Defective genes: 4 (–/–)

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

d

27
Q

Defective genes: 3(–/-a)

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

c

28
Q

Defective genes: 2(–/aa)

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

a

29
Q

No hematologic abnormality

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

a

30
Q

Fetal or neonatal death with severe anemia

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

d

31
Q

Chronic hemolytic anemia

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

c

32
Q

Asymptomatic, mild anemia

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

b

33
Q

Hydrops Fetalis

a. a-thalassemia silent carrier
b. a-thalassemia minor
c. Hemoglobin H disease
d. Hemoglobin Bart

A

d

34
Q

Symptoms appear at 6-24 months of age

a. Alpha thalassemia
b. Beta thalassemia

A

b

35
Q

Symptoms appear at 6-24 months of age

a. Alpha thalassemia
b. Beta thalassemia

A

b

36
Q

Hemoglobin synthezed:
Hemoglobin F
Hemoglobin A2

a. Alpha thalassemia
b. Beta thalassemia

A

b

37
Q

Asymptomatic; Normal hematologic parameters

a. b-thalassemia silent carrier
b. b-thalassemia minor
c. Thalassemia intermedia
d. Thalassemia major

A

a

38
Q

Asymptomatic; Mild anemia

a. b-thalassemia silent carrier
b. b-thalassemia minor
c. Thalassemia intermedia
d. Thalassemia major

A

b

39
Q

Transfusion dependent; Severe anemia

a. b-thalassemia silent carrier
b. b-thalassemia minor
c. Thalassemia intermedia
d. Thalassemia major

A

d

40
Q

Non-transfusion dependent; mild to moderate anemia

a. b-thalassemia silent carrier
b. b-thalassemia minor
c. Thalassemia intermedia
d. Thalassemia major

A

c

41
Q

Cooley’s anemia

a. b-thalassemia silent carrier
b. b-thalassemia minor
c. Thalassemia intermedia
d. Thalassemia major

A

d

42
Q

Causes: Interference in heme synthesis; Defective iron incorporation to
developing RBCs

a. IDA
b. Anemia of Chronic inflammation
c. Thalassemia
d. Sideroblastic anemia

A

d

43
Q

In Sideroblastic anemia, presence of ringed sideroblast in the ___________

A

Bone marrow

44
Q

What causes acquired sideroblastic anemia

A

Lead poisoning

45
Q

What causes Inherited sideroblastic anemia?

A

Porphyria

MTAP 2 Hematology Part 1 (19 decks)

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