3.2 Heme synthesis

Question 1

Heme synthesis occurs on 2 organs of the bone marrow erythroid precursors

Answer 1

Mitochondria

Cytoplasm

Question 2

Heme synthesis starts and ends in the mitochondria.

T or F

Answer 2

T

Question 3

The precursors are glycine, succinyl CoA, and pyridoxal phosphate are all seen in what organ?

Answer 3

Mitochondria

Question 4

glycine, succinyl CoA, and pyridoxal phosphate are needed for the production of _________________

Answer 4

Aminolaevulinic Acid

Question 5

Vit B6 is seen in wat organ for heme synthesis?

Answer 5

Mitochondria

(Pyridoxal phosphate

Question 6

Aminolaevulinic acid is seen in what organ for the production of heme synthesis?

Answer 6

Mitochondria

Question 7

From the ALA, it produces _______________, with the help of ALA dehydratase.

Answer 7

porphobilinogen

Question 8

After porphobilinogen, there is a synthesis of hydroxymethylbilane, uroporphyrinogen, coproporphyrinogen which are seen in what organ for heme synthesis?

Answer 8

Cytoplasm

Question 9

What is the enzyme to convert porphobilinogen to hydroxymethylbilane?

Answer 9

PBG deaminase

Question 10

What is the enzyme to convert hydroxymethylbilane to uroporphyrinogen?

Answer 10

Uroporphyrinogen III synthase

Question 11

What is the enzyme to convert uroporphyrinogen to coproporphyrinogen?

Answer 11

uroporphyrinogen III decarboxylase

Question 12

From coproporphyrinogen, the synthesis goes back to the mitochondria to convert into?

Answer 12

Protoporphyrinogen IX

Question 13

Protoporphyrinogen IX converts in to protoporphyrin by the use of what enzyme

Answer 13

Protoporphyrinogen oxidase

Question 14

protoporphyrin converts into heme with what enzyme that inserts iron into heme molecule?

Answer 14

Ferrochelatase