6.2 RBC Inclusions and Abnormalities Flashcards
Appearance in Wright’s Stain:
Bluish Tinge throughout cytoplasm
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
a
Appearance in Wright’s Stain:
Dark blue-purple punctate granules; content: DNA Remnants
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
c
Appearance in Wright’s Stain:
Dark blue-purple punctate granules; content: Precipitated RNA
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
b
Dark blue-purple punctate granules near RBC membrane; content: Denatured Hemoglobin
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
d
Appearance in Wright’s Stain:
Cannot be seen in Wright’s stain
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
d
Associated disease:
Hemolytic anemia
After treatment for iron, vitamins B12, or folate deficiency
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
a
Associated disease:
G-6PD deficiency
Unstable hemoglobin
Oxidant drugs / Chemicals
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
d
Associated disease:
Lead poisoning,
Megaloblastic anemia
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
b
Associated disease:
Thalassemia, Hemoglobinopathies, Myelodysplastic syndrome (MDS)
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
b
Associated disease:
Post-splenectomy, Same with Coarse Basophilic stippling
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
c
Irregular clusters of light to dark blue granules near the periphery
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
a
Blue rings or figure eight inclusion
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
b
Hexagonal, rod-shaped crystals;”bar or gold” appearance
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
d
Fine evenly dispersed, dark blue granules
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
c
Golf Ball RBCs (pitted; “Rasberry”
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
c
Content: Mitotic SPindle remnants
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
b
Content: Non-heme iron
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
a
Content: Precipitated Beta-globin chains
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
c
Which among is not visible in wright stain?
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
c
Associated with Sideroblastic anemia, Hemoglobinopathies
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
a
Associated with Megaloblastic anemia, MDS
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
b
Hb H disease
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
c
Hb C disease
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
d
Heinz bodies and Hemoglobin H inclusion requires what stain to be seen?
Supravital stain with new Methylene blue
Stain iron deposits
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
a
FInger-like or Quartz-like Crystal of dense hemoglobin protruding from RBC membrane
a. Hemoglobin SC crystal
b. Ringed Sideroblasts
a
Washington monument
a. Hemoglobin SC crystal
b. Ringed Sideroblasts
a
This content contains non heme
a. Hemoglobin SC crystal
b. Ringed Sideroblasts
b
nRBCs in bone marrow with dots surrounding the nucleus
a. Hemoglobin SC crystal
b. Ringed Sideroblasts
b
In ringed sideroblast, the blue fots are iron deposit that can be demonstrated by prussian blue
T or F
T
Associated with Hb SC disease
a. Hemoglobin SC crystal
b. Ringed Sideroblasts
a
Associated Sideroblastic anemia nad myelodysplastic syndrome
a. Hemoglobin SC crystal
b. Ringed Sideroblasts
b