6.2 RBC Inclusions and Abnormalities Flashcards
Appearance in Wright’s Stain:
Bluish Tinge throughout cytoplasm
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
a
Appearance in Wright’s Stain:
Dark blue-purple punctate granules; content: DNA Remnants
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
c
Appearance in Wright’s Stain:
Dark blue-purple punctate granules; content: Precipitated RNA
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
b
Dark blue-purple punctate granules near RBC membrane; content: Denatured Hemoglobin
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
d
Appearance in Wright’s Stain:
Cannot be seen in Wright’s stain
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
d
Associated disease:
Hemolytic anemia
After treatment for iron, vitamins B12, or folate deficiency
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
a
Associated disease:
G-6PD deficiency
Unstable hemoglobin
Oxidant drugs / Chemicals
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
d
Associated disease:
Lead poisoning,
Megaloblastic anemia
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
b
Associated disease:
Thalassemia, Hemoglobinopathies, Myelodysplastic syndrome (MDS)
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
b
Associated disease:
Post-splenectomy, Same with Coarse Basophilic stippling
a. Diffuse Basophilia
b. Coarse Basophilic Stippling
c. Howell Jolly Bodies
d. Heinz bodies
c
Irregular clusters of light to dark blue granules near the periphery
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
a
Blue rings or figure eight inclusion
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
b
Hexagonal, rod-shaped crystals;”bar or gold” appearance
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
d
Fine evenly dispersed, dark blue granules
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
c
Golf Ball RBCs (pitted; “Rasberry”
a. Pappenheimer bodies
b. Cabot Rings
c. Hemoglobin H inclusion
d. Hemoglobin C Crystal
c