3.4 Hemoglobin assembly

Question 1

Intrauterine Phase:

Gower 1: 2________ and 2 ______

Answer 1

Epsilon, Zeta

Question 2

Intrauterine Phase:

Gower II: 2________ and 2 ______

Answer 2

Epsilon, Alpha

Question 3

Intrauterine Phase:

Portland: 2________ and 2 ______

Answer 3

Gamma, Zeta

Question 4

Newborn:

Most predominant hemoglobin in the first 6 months of life? (60-90%)

Answer 4

Hemoglobin F

Question 5

Newborn:

This hemoglobin increases after 6 months (10-40%)

Answer 5

Hemoglobin A

Question 6

Newborn:

HbF: 2______ and 2______

Answer 6

Alpha, Gamma

Question 7

Newborn:

HbA: 2______ and 2______

Answer 7

Alpha, Beta

Question 8

2 Years Through Adulthood:

This hemoglobin is more than 95%

Answer 8

HbA

Question 9

2 Years Through Adulthood:

This hemoglobin is <3.5%

Answer 9

Hba 2

Question 10

2 Years Through Adulthood:

This hemoglobin is 1-2%

Answer 10

HbF

Question 11

2 Years Through Adulthood:

Hb A: 2________ and 2________

Hb A 2: 2________ and 2________

Hb F: 2________ and 2________

Answer 11

Alpha, Beta
Alpha, Delta
Alpha, Gamma

Question 12

What condition is associated if there is a problem in the production of globin chains? Decreased rate of globin chain synthesis?

Answer 12

Thalassemia

Question 13

What condition is associated if the composition of the globin chain is abnormal? There is an amino acid substitution on globin chains?

Answer 13

Hemoglobinopathy