8.2 Lab assessment of body iron status Flashcards
Indirect measure of Transferrin levels; represents all binding sites available
a. Serum iron
b. Total iron Binding capacity
c. % Transferrin Saturation
d. Serum Ferritin
b
Indicates available Transport iron subject to diurnal variation
a. Serum iron
b. Total iron Binding capacity
c. % Transferrin Saturation
d. Serum Ferritin
a
Formula: (πΊππππ ππππ Γ πππ) / TIBC
a. Serum iron
b. Total iron Binding capacity
c. % Transferrin Saturation
d. Serum Ferritin
c
Indicates available Storage iron
Drawback: It is considered an APR (Acute phase Reactant)
a. Serum iron
b. Total iron Binding capacity
c. % Transferrin Saturation
d. Serum Ferritin
d
Reference value:
20%-55%
a. Serum iron
b. Total iron Binding capacity
c. % Transferrin Saturation
d. Serum Ferritin
c
Reference value:
50-160ug/dL
a. Serum iron
b. Total iron Binding capacity
c. % Transferrin Saturation
d. Serum Ferritin
a
Reference value:
250-400 ug/dL
a. Serum iron
b. Total iron Binding capacity
c. % Transferrin Saturation
d. Serum Ferritin
b
Reference value:
40-400ng/mL
a. Serum iron
b. Total iron Binding capacity
c. % Transferrin Saturation
d. Serum Ferritin
d
Gold standard for assessment of iron stores
Prussian Blue staining
________ iron reacts with the reagent (__________________) to
produced dark blue granules
FERRIC
Potassium ferrocyanide
Increased levels indicate iron deficiency or rapid erythropoiesis (hemolytic anemia)
a. Soluble Transferrin Receptor (sTfR)
b. RBC Zinc PRotoporphyrin (ZPP)
a
- Accumulates when iron is not incorporated into heme and zinc binds instead.
a. Soluble Transferrin Receptor (sTfR)
b. RBC Zinc PRotoporphyrin (ZPP)
b
Greatly elevated when ferrochelatase is impaired (e.g lead poisoning)
a. Soluble Transferrin Receptor (sTfR)
b. RBC Zinc PRotoporphyrin (ZPP)
b
Reference Value:
1.15-2.75 mg/L
a. Soluble Transferrin Receptor (sTfR)
b. RBC Zinc PRotoporphyrin (ZPP)
a
Reference Value:
<80 ug/dL
a. Soluble Transferrin Receptor (sTfR)
b. RBC Zinc PRotoporphyrin (ZPP)
b
