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Infektiologie > 9. Syphilis > Flashcards

9. Syphilis Flashcards

1
Q

(Lues)

Stadien (6)

A
  • primäre
  • sekundäre
  • latente Frü-
  • latente Spät-
  • tertiäre
  • quartäre
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2
Q

(Lues)

primäre Syphilis: Befunde (2)

A
  • schmerzloses Ulkus
  • schmerzlose reginäre Lymphadenopathie
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3
Q

(Lues)

schmerzloses Ulkus: Begriffe (2)

A
  • Ulcus durum
  • harter Schanker
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4
Q

(Lues)

sekundäre Syphilis: Befunde (6)

A
  • Alopecia specifica areolaris
  • okuläre Syphilis
  • Plaques muqueuses
  • polymorphes Exanthem
  • Polyskleradenitis
  • Condylomata lata
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5
Q

(Lues)

Condylomata lata

A

nässende breite erodierte Papeln in Intertrigines und Genital-/Analregion

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6
Q

(Lues)

latente Frühsyphilis: Definition

A

symptomfreies Intervall im ersten Jahr

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7
Q

(Lues)

latente Spätsyphilis: Definition

A

symptomfreies Intervall nach einem Jahr

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8
Q

(Lues)

tertiäre Syphilis: Befunde (2)

A
  • Gummen
  • kardiovaskuläre Syphilis
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9
Q

(Lues)

Gummen

A

granulomatöse Gewebeveränderungen mit Neigung zur Ulzeration

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10
Q

(Lues)

quartäre Syphilis: Befund

A

Neurosyphilis

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11
Q

(Lues)

Infektiosität

A

hoch in Stadien I und II

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12
Q

(Lues)

Komplikationen (2)

A
  • Lues maligna
  • konnatale Syphilis
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13
Q

(Lues)

Hutchinson Trias

A
  • Keratitis parenchymatosa
  • Innenohrschwerhörigkeit
  • Tonnenzähne
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13
Q

(Lues)

Lues maligna: Befund

A

multiple Ulzerationen (schwerer Verlauf bei Immunsuppression)

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14
Q

(Lues)

konnatale Syphilis: Befund

A

Hutchinson Trias

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15
Q

(Lues)

Stufendiagnostik (3)

A
  1. erregerspezifischer Suchtest (IgM/IgG)
  2. erregerspezifischer Bestätigungstest
  3. nicht-Treponema-spezifische Tests (Reagin-Tests)
16
Q

(Lues)

erregerspezifische Suchteste (3)

A
  • TPPA: Treponema-pallidum-Partikel-Agglutinationstest
  • TPLA: Treponema-pallidum-Latexagglutinationstest
  • TPHA: Treponema-pallidum-Hämagglutinationstest
17
Q

(Lues)

erregerspezifische Bestätigungsteste (2)

A
  • FTA-Abs: Fluoreszenz-Treponema-AK-Absorption
  • ELISA oder Westernblot IgM/IgG
18
Q

(Lues)

nicht-Treponema-spezifische Tests: Zweck

A

Aktivitätsmarker

19
Q

(Lues)

nicht-Treponema-spezifische Tests (2)

A
  • RPR: Rapid Plasma Reagin
  • VDRL: Veneral Disease Research Laboratory
20
Q

(Lues)

Therapie der Wahl

A

Penicillin i.m.

21
Q

(Lues)

Penicillin i.m.: Dosis (2)

A
  • Frühsyphilis: 2,4 Mio IE

-Spätsyphilis: 2,4 Mio IE (0-8-15)

22
Q

(Lues)

Penicillin i.m.: Nebenwirkung

A

Herxheimer-Reaktion

23
Q

(Lues)

Herxheimer-Reaktion: Leitsymptom

A

plötzlich einsetzendes Fieber binnen 24h ab Therapiebeginn

Infektiologie (17 decks)

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