5. Herpes-Simplex-Enzephalitis Flashcards by Ian Paglione

Q

(HSVE)

Erreger (2)

A

HSV-1 bei Erwachsenen
HSV-2 bei Säulingen

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Q

(HSVE)

Pathophysiologie

A

nekrotisierend-hämorrhagische Entzündung

insb. der Temporallapen

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Q

(HSVE)

Letalität

A

90% (unbehandelt)

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Q

(HSVE)

Komplikationen (2)

A

kognitive Defizite
Verhaltensauffälligkeiten

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Q

(HSVE)

Differenzialdiagnose

A

Autoimmunenzephalitis

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Q

(HSVE)

Autoimmunenzephalitis: häufigste Manifestation

A

limbische Enzephalitis

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Q

(HSVE)

Autoimmunenzephalitis: Serologie

A

LGI1-AK

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Q

(HSVE)

Autoimmunenzephalitis: Bildgebung der Wahl

A

MRT

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Q

(HSVE)

Autoimmunenzephalitis: Befunde in der Bildgebung

A

temporomediale multifokale Hyperintensitäten in T2 und FLAIR

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Q

(HSVE)

Autoimmunenzephalitis: Therapie

A

Glucocorticoide i.v.

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Q

(HSVE)

Symptome (2)

A

Allgemein-
neurologische und psychiatrische-

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Q

(HSVE)

Allgemeinsymptome (3)

A

hohes Fieber
Kopfschmerzen
Abgeschlagenheit

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Q

(HSVE)

neurologische und psychiatrische Symptome (3)

A

Bewusstseinsstörungen
epileptische Anfälle
fokale Defizite

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Q

(HSVE)

Bildgebung der Wahl

A

MRT

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Q

(HSVE)

MRT-Befund

A

bilaterale asymmetrische Befunde in den Temporallappen

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Q

(HSVE)

MRT-Befund: Einbeziehung (2)

A

limbisches Systems

(Gyrus cinguli und Hippocampus)

Inselregion

Q

(HSVE)

MRT-Befund: Ausdehnung

A

nach frontobasal

Q

(HSVE)

Labordiagnostik

A

Liquordiagnostik

Q

(HSVE)

Liquordiagnostik: Parameter (5)

A

ZELEG

Zellart
Erscheinung
Laktat
Eiweiß
Glucose

Q

(HSVE)

Liquordiagnostik: Befunde (5)

A

Zellart: massive lymphozytäre Pleozytose
Erscheinung: gelbliche Flüssigkeit
Laktat: ↔︎
Eiweiß: ↑
Glucose: ↔︎

Q

(HSVE)

apparative Diagnostik

A

EEG (Elektroenzephalografie)

Q

(HSVE)

EEG-Befund

A

generalisierte EEG-Rhythmusverlangsamung

Q

(HSVE)

Therapie der 1. Wahl

A

Aciclovir i.v. über 14d

Q

(HSVE)

Aciclovir: Nebenwirkung

A

nephrotoxisch

(HSVE) Therapie der 2. Wahl

Foscarnet i.v. über 21d

(HSVE) Foscarnet: Indikation

bei Aciclovir-Resistenz