9. Substance use in children

Question 1

4 symptoms of autonomic over-reactivity in NAS?

Answer 1

yawning, sneezing, mottling and fever

Question 2

drug causing withdrawal and birth defects in neonates?

Answer 2

Alcohol

Question 3

partial mu agonist used to tx NAS?

Answer 3

buprenorphine

Question 4

wt is use of prescription drugs in boys associated with?

Answer 4

sexual dating violence

Question 5

best evidenced medical benefit of THC?

Answer 5

chemotherapy induced nausea and vomiting

Question 6

5 step MOA of opiates

Answer 6

1. activate opiate receptors in locus coeruleus in brain stem
2. dec cAMP
3. increased K efflux
4. decrease Ca influx
5. decrease Norepinephrine release

Question 7

α2 receptor agonist used as adjunct tx for NAS?

Answer 7

clonidine

Question 8

drug causing baby iritability?

Answer 8

marijuana

Question 9

2 theories on pathogenesis pathways of opioid withdrawal?

Answer 9

dissuse hypersensitivity
and
alternative pathway

Question 10

where is norepinephrine synthesized?

Answer 10

locus coeruleus

Question 11

patholophysiologic cause of NAS?

Answer 11

when opiate is withdrawn, inhibiting effect of norepinephrine is diminished

Question 12

3 locations of CB2 receptor?

Answer 12

immune cells, retina and spleen

Question 13

drug used for NAS when mother is using opiates and benzos? mech?

Answer 13

phenobarbital

GABA receptor antagonist

Question 14

drug causing delayed baby withdrawal?

Answer 14

benzodiazapines

Question 15

wt is prescription drug use in girls associated w?

Answer 15

physical dating violence

Question 16

classic cause of NAS?

Answer 16

opioids

Question 17

hallmark of neonatal withdrawal?

Answer 17

jitters

Question 18

symtoms of cerebral irritation in NAS?

Answer 18

irritable and hypertonia

Question 19

physiologic effect of THC

Answer 19

dec inhibitory GABA release –>less refractory period –> quicker firing of neurons

Question 20

location of CB1 receptor?

Answer 20

CNS