10. Arboviruses

Question 1

arbovirus associated with shock syndrome? hw does it develop?

Answer 1

Denguevirus of serotype 1, 3 or 4

then denguevirus 2 –>shock

Question 2

virus causing symptoms similar to dengue virus? why is it important to distinguish?

Answer 2

Chikungunya virus.

tx with NSAIDs improves chikungunya but enhances hemorrhage in Dengue

Question 3

2 vectors for flavivirus?

Answer 3

mosquitos and ticks

Question 4

hw to distinguish Togavirus from Flavivirus?

Answer 4

toga is protease sensitive, falvi is resistent

Question 5

first stage of togavirus infection
hw is it indroduced?
site of replicaiton?
3 symptoms?

Answer 5

gets in blood via insect bite

• multiplies in rough RE system (esp. spleen and lymph nodes)

viremia –> fever, vomiting, pain

Question 6

arboviral disease common in nicolas county WV?

Answer 6

LaCrosse encephalitis

Question 7

characteristic of yellow fever virus?

Answer 7

black vomit

Question 8

Family containing alphavirus? 3 disease names?

Answer 8

Togaviridae.

Eastern/western/venezualan equine encephalitis

Question 9

arbovirus associated with hemoconcentration?

tx?

Answer 9

Dengue fever virus

hydration

Question 10

3 ways West nile virus can be transmitted?

Answer 10

insect
blood transfusions
organ transplant

Question 11

Primary host for zoonotic diseases? 2 ways its transmitted to seconday host?

Answer 11

animal.
host is accidentally infected.
insect or shit

Question 12

second stage of togacvirus infection?

2 symptoms

Answer 12

virus crosses BBB –> encephalitis and lesions lesions throughout the brain –> neuronophagia and encephalomalacia

Question 13

2 main viruses in flavivirus?

Answer 13

yellow fever and dengue

Question 14

3 viruses diagnosed via trioplex TR-PCR?

Answer 14

zika, chikunguya and Dengue

Question 15

where do arboviruses replicate? where do they cause disease?

Answer 15

replicate in host and insect

only cause disease in host

Question 16

2 families of viruses causing encephalitis +hemorrhagic fever?
structure and genome?

Answer 16

Toga and Flavi

+SS RNA
Icosahedral + Envelope

Question 17

structure and genome of bunyavirus?
-/+
segmented?
RNA/DNA
helical/icosahedral

Answer 17

• SS segmented RNA

Helical + env

Question 18

virus with core particles that resemble ribosomes?

Answer 18

Arenaviridae

Question 19

Name the virus and family:

asceptic meningitis, flu symptoms

Answer 19

Lymphocytic choriomeningitis virus

Arenaviridae

Question 20

Name the virus and family:

Skin hemorrhages, muscle aches

Answer 20

Lassa fever

Arenaviridae

Question 21

Name the virus and family:

petechiae, bleeding from GI/GU/nasal tracts

Answer 21

Tacaribe complex

Arenavirus

Question 22

Name the genus:

Creimean-Congo hemorrhagic fever

Answer 22

Orthobunyavirus

Question 23

Name the genus:

photophobia, stiff neck

Answer 23

Phlebovirus

Question 24

Name the genus:

Pulmonary syndrome

Answer 24

Hantavirus

Question 25

2 viruses than can be transmitted by blood transfusions?

Answer 25

WNV

Zika

Question 26

structure and genome of arenavirus?
-/+
segmented?
RNA/DNA
helical/icosahedral

Answer 26

• SS circular segmented RNA

helical + Envelope

Question 27

3 Arenavirus diseases?

Answer 27

Lymphocytic choriomeningitis virus
Lassa fever
Tacarbine