4. Schizophrenia Flashcards
df illusions
misperceptions of real environmental objects or events
3 DSM criteria for schizophrenia? (5 specific for criteria 1)
- at least 2 of the following: delusions, hallucinations, disorganized speech, disorganized behavior and negative symptoms
- symptoms are impairing
- symptoms last 6+ months
syndrome associated with shiz? genetic mutation
DiGeorge syndrome. 22q11 deletion
wn to use long acting antipsychotic injections?
pt has history of violence of medication noncompliance
part of brain causing hyperloactinemia w antipsychotics? origin? projects to?
tubounfundibular
origin - hyopthalamus
projects - pituitary
3 structural/functional abnormalities seen in schiz?
- over-activity of limbic areas
- under-activity in frontal lobes
- enlargement of the lateral ventricles
wt is Capgras syndrome?
matchbox sign?
Morgellons?
delusion that someone in pts life has been replaced w a clone
matchbox sign - belief stuff is under skin
Morgellons - thread-like fibers under skin
5 negative symptoms of schizophrenia?
flattened affect lost sense of self avolition (difficulty initiating goals) poverty of thought poverty of speech
Hw is complement involved in schiz?
C4A expression in brain is correlated
Df Psychosis? compare to neurosis
loss of contact w reality
Psychosis - disease of mind
Neurosis - disease of the nervous system
are the following poor or positive prognosis factors: abrupt onset? negative symptoms? family history of mood disorders? lack of mood symptoms? childhood onset?
abrupt = positive negative symptoms = poor family history of mood disorders = positive lack of mood symptoms = poor childhood onset = poor
onset of schizophrenia?
bimodal - late teens to early 20s and late 40s
Wt is CATCH 22
DiGeorge Cardiac abnormality Abnormal facies Thymic aplasia Cleft palate Hyoplaclemia/hyoparathyroidism 22q11
3 times to hospitalize schizophrenic pts?
- violent command hallucinations
- extreme paranoia
- significant confusion
wt gene is most strongly associated w schizophrenia?
MHC locus on chromosome 6
largest contributing symptom to day-to-day dysfunction?
cognitive symptoms
part of brain responsible for positive symptoms? origin? wr does it project?
Mesolimbic
origin - VTA
projects - limbic
Part of brain causing extrapyramidal symptoms and movement related side effects of antipsychotics? origin? wr does it project
Nigrostriatal
origin - substantia nigra
projects to - corpus striatum
Lifetime prevelance of schizophrenia?
1.1%
hw can microglia cause schiz?
inappropritate synaptic pruning
3 Neurotransmitters altered in schizophrenia? wc is associtedw cognitive deficits?
inc Dopamine
dec. serotonin
dec. glutamate - linked to cognitive deficits
wt is the strongest genetic link of schizophrenia (50% risk)?
identical twins
df brief psychotic disorder
1 schizo symptom lasting 1 day-1 month
4 DSM 5 criteria for schizoaffective disorder?
- same as 1 for schizophrenia
- delusions or hallucinations for 2 or more weeks in the absence of major mood episode
- symptoms are long
- not attributed to medication or substance
df delusional disorder
1 or more delusions w otherwise retained functional behavior
wt is the goal of individual therapy for shizo?
supportive therapy:
df delusions?
abnormalities of thought content
df schizophreniform disorder
schizo criteria lasting less than 6 months
part of brain responsible for negative symptoms? origin? wr does it project?
Mesocortical
origin - VTA
projects - prefrontal/frontal areas
approach of schizophrenia tx?
recovery oriented
