26. CNS Tumors

Question 1

Glioma w poached egg appearance?

4 genetic links?

Answer 1

Oligodendroglioma

Genetics: IDH1, IDH2, 1p and 19q

Question 2

child presents visual symptoms and growth retardation, glioma type?

Answer 2

Craniopharyngioma

Question 3

most radiosensitive glioma?

Answer 3

medulloblastoma

Question 4

Glioma most often occuring in midline of cerebelum?

histo note?

Answer 4

Medulloblastoma

histo: small round blue cells

Question 5

hw do brain tumors originate?

Answer 5

progenitor cells

Question 6

Tumor arrising from meninges?

2 MRI notes?

2 Histo Ntes?

Answer 6

Meningioma

MRI: dural tail and contrast enhancing

Histo: Psammomatous and Syncytial (whorls of cells)

Question 7

tumor syndrome w capillary hemangioblastomas?

wt are they at increased risk for?

Answer 7

von-Hippel-Lindau

Increased risk of renal cell carcinoma

Question 8

df glioma?

Answer 8

tumor of brain or spinal cord

Question 9

gene and chromosome involved w neurofibromatosis type 2?

Answer 9

NF2 gene on chromosome 22

Question 10

brain tumor presenting in 4th ventricle of kids?

histo appearance?

Answer 10

ependymoma

perivascular pseudorosettes

Question 11

tumor that can obstruct foramina of Monro?

Answer 11

Colloid cyst of third ventricle

Question 12

basic difference between neurofribromatosis type 1 and type 2?

Answer 12

type 1 involve skin and plexiform

type 2 involve CNS

Question 13

glioma w Rosenthal fibers?

Answer 13

Pilocytic astrocytoma

pilocyte = hair like cell (pili)

Question 14

child presents w tumor in lateral ventricle, Diagnosis?

Answer 14

choroid plexus papiloma

Question 15

tumor syndrome w hamartomas?

2 genes? normal functions?

Answer 15

Tuberous sclerosis

9q - Hamartin
16p - Tuberin
suppress mTOR

Question 16

hw to diagnose brain tumor?

Answer 16

MRI w contrast

Question 17

Glioma with spindle cell lesions?
associated chromosome?
3 subtypes? wc has highest potential for malignant transformation?

Answer 17

Neurofibroma
NF1 on chromosome 17

Superficial
Diffuse
Plexiform - transformation

Question 18

where do choroid plexus papillomas occur in children? adults?

Answer 18

Children - lateral ventricle

Adults - 4th ventricle

Question 19

tumor that resembles medulloblastoma but occurs in cerebral hemispheres?

Answer 19

CNS PNET

Question 20

brian tumor w small round blue cells?

location?

Answer 20

medulloblastoma

cerebellum only

Question 21

contrast enhancing astrocytoma?

3 histo notes?

Answer 21

Glioblastoma

histo: necrosis, vascular proliferation and pseudopalisading

Question 22

nerve tumor presenting w tinnitus and hearing loss?

Answer 22

schwannoma/acoustic neuroma

Question 23

the only unequivocal risk factor for brain tumors?

Answer 23

ionizing radiation

Question 24

5 most common sites for metastatic tumors to CNS?

Answer 24

Lung, Breast, Skin, Kidney, GI

Lots of Bad Stuff Kills Glia

Question 25

3 tumors associated w neurofibromatosis type 2 (NF2)

Answer 25

Schwannoma
Meningioma
Ependymoma

Question 26

glioma seen in immunosuppressed patients?

Cell causing glioma?

Answer 26

Primary brain lymphoma

B cells

Question 27

Glioma presenting in pituitary stalk? where does it come from?
2 histological types?
- which is children
- which has keratin, calcification and cysts

Answer 27

Craniopharyngioma
- arise from remnants of Rathkes pouch

Asamantinomatous

• children
• calcifications, keratin, cysts

Papillary
- adults

Question 28

2 tumors presenting as multiple lesions in brain?

Answer 28

Lymphoma

PNET

Question 29

2 tumors in the cerebellum?

Answer 29

Medulloblastoma

Pilocytic astrocytoma