17. Pain Drugs

Question 1

3 things that do not develop tolerance to opioids?

Answer 1

miosis, constipation and respiratory effects

Question 2

MOA of Carbamazepine?

use?

Answer 2

stabilizes inactive voltage gated Na Channels.

DOC for Trigeminal neuralgia

Question 3

use for metazalone?

Answer 3

muscle discomfort

Question 4

Drug used to tx pregnant opioid addicts?

Answer 4

Buprenorphine

Question 5

MOA of Baclofen?

Answer 5

GABA-B receptor activator

Question 6

1st line drugs for neuropathic pain?

Answer 6

antidepressents (NOT SSRIs, only SNRIs and TCAs)

Question 7

metabolite of heroin detectable in urine?

Answer 7

6-monoacetylmorphine (not found in morphine)

Question 8

2 GI AEs of morphine?

Answer 8

biliary pain

constipation

Question 9

drug to treat TMJ?

Answer 9

cyclobenzaprine

Question 10

target of non-opioid analgesics?

Answer 10

inflammatory component of the pain cascade

Question 11

hw is codeine metabolized? enzyme?

product?

Answer 11

O-demethylaiton by CYP2D6 to morphine

Question 12

3 uses for tizanadine? AEs?

Answer 12

muscle spacticity, tension headaches and low back pain

CV AEs

Question 13

drug to tx low back pain and tension headaches?

Answer 13

Tizanadine

Question 14

MOA of gabapentin

Answer 14

a2d ligand –> reduces activaiton of Ca channels

Question 15

2 Uses of Baclofen? black box warning?

Answer 15

Spasticity and hiccups

Avoid abrupt withdrawal

Question 16

drug to tx muscle discomfort?

Answer 16

Metazalone

Question 17

drug to tx tetanus?

Answer 17

Methocarbamol

Question 18

2 uses for methocrbamol

Answer 18

muscle spasms and tetanus

Question 19

2 uses for cyclobenzaprine?

Answer 19

acute muscle spasms and TMJ.

Question 20

where do α2 adrenergic agonists act to tx pain?

Answer 20

dorsal horn

Question 21

in wt pt population should centrally active muscle relaxants be used w caution?

Answer 21

elderly