13. Drugs of abuse

Question 1

Drug to reduce Cocaine craving?

Answer 1

Bromocriptine

Question 2

Major metabolite of nicotine?

Answer 2

Cotinine

Question 3

ABCDE of adiction

Answer 3

inability to Abstain
impaired Behavioral control
Craving
Diminished recognition of problems
dysfunctional Emotional response

Question 4

opioid drug w ceiling effect?

Answer 4

buprenorphine

Question 5

opioid antagonist?

Answer 5

naltroxene

Question 6

3 phases of opiod tx?

Answer 6

1. Induction - finding the right dose
2. maintenance - providing stability
3. detoxification - weaning off

Question 7

% of west virginians w illicit drug abuse?

Answer 7

4%

Question 8

% of west virginians not being treated for drug abuse?

Answer 8

90% dont get tx

Question 9

do drugs to tx addiction work thru the same receptor?

Answer 9

yes, they have to work thru the same receptor

Question 10

drug to tx Dysphoria (unease) and restlessness associated w opioid withdrawal?

Answer 10

Clonidine

Question 11

drug to tx myalgias and arthralgias in opioid withdrawal?

Answer 11

NSAIDs

Question 12

drug to tx GI symptoms of opioid withdrawal?

Answer 12

loperamide

Question 13

Roofie scientific name?

Answer 13

Flunitrazepam

Question 14

drug used for power naps?

Answer 14

Propofol

Question 15

Amphetamine mech of addiction?

wc amphetamine crosses BBB easiest?

Answer 15

directly increases levels of dopamine in nucleus accumbens

Methamphetamine

Question 16

MOA of low dose amphetamines?
moderate dose?
high dose?
2 mechs at all doses

Answer 16

low - release NE
moderate - release NE and DA
high - release NE, DA and 5-HT
all - block reuptake and inhibit MAO

Question 17

why do meth addicts lose weight?

Answer 17

reduced appetite and increased activity

Question 18

cause of meth mouth?

Answer 18

reduced blood flow to gums and poor dental hygiene

Question 19

first line tx for amphetamine OD?

tx if first line is not enough? (4 specifics)

Answer 19

Benzodiazepines (IV)

2nd - antipsychotic (chlorpromazine, haloperidol, droperidol, ziprasidone)

Question 20

3 Amphetamine withdrawal symptoms?

Answer 20

depression
fatigue
hunger

Question 21

Acute effects of cocaine?

chronic effects?

Answer 21

acute - prolongation of DA in limbic system –> euphoria

chronic - DA depletion –> cravings

Question 22

4 metabolites of cocaine? wc only w alcohol?

Answer 22

benzoylexgonine
ecgonine
norcaine
Cocaethylene (w alcohol)

Question 23

Drug that cannot tx cocaine toxicity?

Answer 23

beta blockers

Question 24

chemical structure of nicotine?

Answer 24

lipid, soluble tertiary amine

Question 25

2 symptoms of nicotine toxicity?

Answer 25

respiratory paralysis

hypotension due to medullary paralysis

Question 26

Rx form of THC?

Answer 26

Dronabinol

Question 27

biochemically, why are drugs addictive? specific part of brain

Answer 27

increase DA in nucleus acumbens

Question 28

2 ways Aclohol affects opioid mech?

Answer 28

stimulates GABA

stimulates opioid transmisison

Question 29

4 systems involved in opioid addiction?

Answer 29

biological
psychological
social
spiritual

Question 30

recreational drug causing paranoid-schizophrenia like state?

Answer 30

Amphetamines

Question 31

symptom of cocaine toxicity?

Answer 31

cardiac failure. rapid elevation of blood pressure

Question 32

cocaine toxicity:
1 drug to tx agitation?
2 for hypertension?
3 for MI?

Answer 32

agitation - benzos
hypertension - benzos, phentolamine
MI - aspirin, nitroglycerin, phentolamine