9/13 Connective Tissue - Brauer (Completed) Flashcards
What are the main cells of Connective Tissue? 4
HAM COF
Hematopoietic stem cells
Adipocytes
Mesenchymal cells (CT stem cells)
Chondrocytes
Osteoblasts
Fibroblasts (collagen and glycans)
What type of fibers form the supportive CT mesh work? 5
Reticular Fibers
What is the most common type of collagen? 5
Type I
What causes Scurvy? 6
Lack of Vit. C - a cofactor involved in cross-linking collagen fibers
What is the problem in Ehlers-Danlos Syndrome? 6
Abnormal collagen synthesis producing weak collagen fibers
What kind of inheritance is seen in Marian’s Syndrome? 8
Autosomal Dominant
What is the problem in Marfan’s Syndrome? 7
Mutation in Fibrillin-1 gene
What are the life threatening cardiovascular anomalies seen in Marfan’s Syndrome? 7
Dissecting aneurysms
Mitral Prolapse
What components will be found within proteoglycans? 8
Chondroitins
Heparans
Keratans
What is the role of Hyaluronan or Hyaluronic acid? 8
Provide a backbone which proteoglycans can attach to
What is the EC matrix of the umbilical cord referred to as? What is it the source of? 10
Warton’s Jelly
Mesenchymal stem cells
What kind of potently do Adult mesenchymal cells have? 11
They’re multipotent stem cells
What are examples of loose CT? 12
Areolar
Adipose
Reticular
What are examples of dense CT? 12
Regular
Irregular
Elastic
What is Areolar loose CT? 13
Low density tissue w/ both fixed and wandering cells
What is reticular loose CT? Give an example. 13
Reticular fibers forming a supportive mesh framework that holds free cells
Ex. Bone Marrow
Give an example of dense irregular CT? 13
Dermis of the skin
Give an example of Dense regular CT? 13
Tendons connecting skeletal muscle to bone
What are the fixed cells found in loose Areolar CT? 14
Fibroblasts
Adipocytes
Mesenchymal cells
What are the wandering cells found with in loose areolar CT? 14
Macrophages
Mast Cells
Leukocytes/Lymphocytes
Plasma cells
What are the function of loose CT? 15
Supports and bind other tissues
Holds body fluids
Defends against infection
Where would you find loose CT? 15
Around BVs, muscles, and nerves
Makes up the lamina propria
What do you not find a lot of in Adipose CT? 17
ECM
Where would you find Reticular CT? 19
Liver
Bone Marrow
Lymph nodes
Spleen
What is the principle cell type found in dense irregular CT? 20
Fibroblasts
What characterizes dense irregular CT? 20
Interwoven collagen fibers running in a random pattern
Where would we find Dense Irregular CT? 20
Dermis of skin
Capsules surrounding internal organs
Perichondrium/periosteum
Fascia
What characterizes Dense Regular CT? 21
Tightly packed, regular arrangement of collagen fibers
Why do tendons (dense regular CT) take such a long time to heal? 21
Due to being poorly vascularized
Where can we find Dense Regular CT? 21
Tendons
Ligaments
Aponeuroses
Dense fascia, joint capsules
Where would we find Elastic CT? 22
BV walls
Bronchioles tubes
Special ligaments (ligmentum nuchae)
What is the main role of Fibroblasts? 23
To make and maintain cells of the ECM
What cells do Fibroblasts produce? 23
Collagen
Elastin
Reticular Fibers
Proteoglycans
Glycoproteins
