80 - physical malformation and abnormal stature

Question 1

Dopamine effect on pit?

Answer 1

inhibits prolactin release by ant pituitary

Question 2

GnRH on pit?

Answer 2

stimulates FSH and LH release by ant pituitary

Question 3

Somatostatin on pit?

Answer 3

inhibits GH release

Question 4

Screening during pregnancy

Answer 4

USS to detect physical abnormalities (20 week scan), count number of foetuses, assess foetal heartrate

Combined test at 12 weeks. Blood test and USS for nuchal thickness.

Quadruple test: alpha fetoprotein, hCG, estriol and inhibin A.

Chorionic villus sampling.

Question 5

features of turners

Answer 5

Webbed neck, short stature, diabetes, hypothyroidism, infertility, cardiac defects, amenorrhea, short stature, low set ears, shield chest.

Question 6

Turners genetics

Answer 6

45XO

Question 7

Mx of turners

Answer 7

replace hormones

repair cardiac defects

Question 8

When is early puberty? causes?

Answer 8

Before 8 in girls and 10 in boys. More malignant in boys.

Obesity, drug side effects, tumours, genetic disease

Question 9

When is late puberty? causes?

Answer 9

Post 14 in girls, 16 in boys.

Genetic disease, tumours, eating disorders, drug side effects, hypogonadism, malnutrition. More malignant in girls.