8. Sarkoidose Flashcards

1
Q

(Sarkoidose)

Eponym

A

Morbus Boeck

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2
Q

(Sarkoidose)

Pathophysiologie

A

Störung der T-Lymphozyten-Funktion (Th1-gewichtete T-Helfer-Antwort)

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3
Q

(Sarkoidose)

Prognose

A

Spontanremission

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4
Q

(Sarkoidose)

pulmonale Symptome (3)

A
  • Dyspnoe
  • Husten
  • thorakale Schmerzen
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5
Q

(Sarkoidose)

Komplikation

A

periphere chorioretinale Läsionen

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6
Q

(Sarkoidose)

Sonderformen (2)

A
  • Löfgren-Syndrom
  • Heerfordt-Syndrom
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7
Q

(Sarkoidose)

Löfgren-Syndrom (3)

A

Trias

  • Polyarthritis (insb. Sprunggelenke)
  • Erythema nodosum
  • bihiläre Lymphadenopathie
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8
Q

(Sarkoidose)

Labor: Stufendiagnostik (2)

A
  • Basisdiagnostik
  • Aktivitätsparameter und Therapiekontrolle
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8
Q

(Sarkoidose)

Heerfordt-Syndrom (3)

A

Trias

  • Uveitis (Iridozyklitis)
  • Parotitis
  • Fazialisparese
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9
Q

(Sarkoidose)

Labor: Basisdiagnostik

A

Entzündungsparameter

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10
Q

(Sarkoidose)

Labor: Aktivitätsparameter und Verlaufskontrolle

A

ACE

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11
Q

(Sarkoidose)

Bildgebung der Wahl

A

Röntgen-Thorax

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12
Q

(Sarkoidose)

Bildgebung der 2. Wahl

A

CT-Thorax

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13
Q

(Sarkoidose)

Therapieschema (3)

A
  1. NSAR
    • Glucocorticoide
    • Immunsuppressiva
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14
Q

(Sarkoidose)

invasive Diagnostik

A

Bronchoskopie mit BAL

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14
Q

(Sarkoidose)

Stadieneinteilung der chronischen Sarkoidose: Befund im Röntgen-Thorax (5)

A

0: Normalbefund

I: bihiläre Lymphadenopathie

II: bihiläre Lymphadenopathie mit Lungenbefall

III: Lungenbefall ohne Lymphadenopathie

IV: Lungenfibrose

15
Q

(Sarkoidose)

Bronchoskopie mit BAL: Befund

A

CD4/CD8 Quotient > 5

16
Q

(Sarkoidose)

Biopsie: Befund

A

nicht-verkäsende Granulome

16
Q

(Sarkoidose)

Goldstandard

A

Biopsie von betroffenen Geweben