7. Musculatory System Flashcards
Formative immature cells of muscle; present in fetal stage; func: Mitosis
Myoblast
Nonstriated
Involuntary
Can divide
Smooth muscle
Spindle-shaped muscle tissue
Smooth muscle
Only mature muscle tissue that can divide
Smooth muscle
Striated Voluntary Multinucleated Hypertrophy only Cannot multiply
Skeletal muscle
Location of nucleus of skeletal muscle
Lateral surface
Striated
Involuntary
Cannot multiply;
Hypertrophy only
Cardiac muscle
What type of muscle cell or tissue is the Heart
Cardiac muscle
What connects cardiac muscle cells together
Intercalated discs
Cellular junctions in cardiac muscles
Desmosomes
Gap junctions
Outermost connective tissue layer that covers MUSCLE BELLY
Epimysium
Middle layer covers FASCICLES
Perimysium
Innermost; covers muscle cells or fibers
Endomysium
Connects muscle to bone
Tendon
Connects bone to bone
Ligaments
Group of muscle fibers covered by perimysium
Fascicle
Cell membrane or plasma membrane of muscles made up of phospholipid bilayer
Sarcolemma
Structures that makes up the muscle cell or fiber
Myofibrils
Structures that makes up myofibrils
Myofilaments
2 kinds of Myofilaments
Thin filaments
Thick filaments
Thin filaments is composed of what protein
Actin
Thick filaments are composed of what protein
Myosin
Shape of myosin
Golf club 🏑
Functional/contractile unit of muscle; from Z disc to another Z disc
Sarcomere
🔹Separates one sarcomere to another.
🔹Attachment for thin filaments.
🔹Passes in the middle of the I band
Z discs
Contains thick but no thin filaments (MYOSIN ONLY)
H zone
Passes in the middle of H zone
M line
aka dArk band
A band
aka l”i”ght band
I band
Blocks the myosin binding sites in actin (relax muscle)
Tropomyosin
🔹Holds the tropomyosin in place.
🔹Binding site for Ca ions to allow movt of tropomyosin.
Troponin
Perpendicular sarcolemma
Transverse tubules or T tubules
Endoplasmic reticulum of muscle fiber
Sarcoplasmic reticulum
Storage for calcium
Sarcoplasmic reticulum
Most impt substance for muscular contraction
Calcium
Dilated end sac of sarcoplasmic reticulum
Terminal cisterns
Cytoplasm of a muscle fiber
Sarcoplasm
Stored chains of glucose
Glycogen
Glycogen is mainly stored in
✔️Liver
✔️Skeletal muscle
✔️Adipocytes
Process: glycogen to glucose
Glycogenolysis
Maximum storage of glycogen
2 lbs
Process: glucose to glycogen
Glycogenesis
When does the body produce glycogen
Hyperglycemic state
Hormone responsible for production of insulin (glycogen stored in insulin sensitive cells)
Beta cells of pancreas
🔹Protein that binds OXYGEN = red color of muscle.
🔹Counterpart of RBC (hemoglobin = red color)
Myoglobin
Largest protein of the body found in muscles
Titin
Total muscles in the body
650 muscles
Attachment for THICK filaments
M line
Overlapping thick and thin filaments
A band
Attachment of THIN filaments
Z line or disc
Filaments seen in light or I band
Thin filaments only
aka Theory of muscle contraction
Sliding filament mechanism
% of ICF
40% ICF
% of ECF
20%
What is the resting membrane potential? (mV)
-70mV (-90mV in Guyton)
Most numerous cation in ECF
Na+
Most numerous cation in ICF
K+
Charge inside the cell when it is in resting state or polarized state
Resting membrane potential
1st channel to open once there’s electrical current
Voltage-gated Na+ channels
Why is depolarization and repolarization happens? What process?
(Na goes IN, K goes OUT)
Because of simple diffusion
🔹Na+ influx = cell more + = ______
🔹Wherein, cell from negative to a positive state.
🔹Remove a cell in a polarized state(-)
Depolarization
Channels that are delayed to open (opens after action potential)
Voltage-gated K+ channels
K+ efflux(out) = cell goes back to resting state = ______
🔹Change charge of cell from (+) to (-)
Repolarization
What is the Threshold stimulus to generate an action potential
-55mV
Signal that has potential to trigger an axon
Action potential
Corrects position of Na+(out) and K+(in)
Sodium potassium pumps
Ratio in Na-K pumps
“2PISO3”
2 Potassium IN
3 Sodium OUT
In precontraction phase, an ACTION POTENTIAL from nerve fiber stimulates _____ to open
Voltage-gated calcium channels
Calcium influx causes release of _____ in the NMJ
Acetylcholine (Ach)
It is a neurotransmitter or a chemical messenger (LIGAND)
Acetylcholine
Part of the NMJ where Ach binds
Nicotinic receptors / “Ligand”-gated Na+ channels
Na+ enters muscle fiber (Depolarization) creating a ______
Muscle action potential
Muscle action potential travels to what part of the muscle cell
Sarcolemma and T tubules
Muscle action potential opens _____ which stores Calcium
Sarcoplasmic reticulum
Responsible in releasing calcium ions into the sarcoplasm
Sarcoplasmic reticulum
Where does calcium ions bind
Troponin
What happens when calcium binds to troponin
Troponin moves tropomyosin away from blocking the myosin heads sa actin binding sites
Myosin head will attach to actin known as
Cross bridging
ATP in the myosin head is broken down by (what enzym) into ______
ATP / ATPase = ADP + P
Immediate source of energy
ADP + Phospate
Source of energy
ATP
Occurs when actin moves towards the M line and ADP is released
Power stroke
Actin moves towards M line, Z discs moves towards each other, sarcomere shortens.
Muscle contraction
When does myosin detach from actin
When there is another ATP that binds to myosin head
Detachment of myosin to actin = sarcomere _______
Sarcomere goes back to original place
As long as there are high amounts of _____ and ______ in the sarcoplasm, contraction cycle continues
Ca+ and ATP
This moves calcium back to the sarcoplasmic reticulum
Ca+ active transport pumps
Enzyme that breaks down Ach after it binds to Nicotinic receptors
Acetylcholinesterase
Phenomenon seen in dead body. Muscles are in state of RIGIDITY due to cross bridging (Lysosymes digest SR causing release of Ca resulting to crossbridging but no ATP so myosin doesnt detach to actin = muscles remain contracted)
Rigor mortis
Causative agent or bacteria of botulinum toxin
Clostridium botulinum
Prevents release of Ach in the NMJ resulting to muscle paralysis or relaxation
Botulinum toxin
Poisonous plant; blocks NICOTINIC receptors (close: Ach cannot bind =cant stimulate muscle contraction) Resulting to Muscle paralysis
Curare
Drug derived from Curare
Pancuronium bromide
Drugs used in lethal injection
✔️Thiopental (sedative)
✔️Potassium chloride (to stop heart)
✔️Pancuronium bromide (from curare)
Other name of Succinylcholine
Suxamethonium
Succinylcholine is for
Laryngospasm
Binds to Ach receptors resulting to muscle paralysis.
Used in laryngospasm
Succinylcholine
Other name for creatine phosphate mechanism
Direct phosphorylation
Fuel for creatine phosphate mechanism
Creatine phosphate
End products of creatine phosphate mechanism
1 ATP
1 Creatinine
Other name for GLYCOLYSIS
Anaerobic respiration
Process of breaking down glucose
Glycolysis
Fuel for glycolysis
Glucose
End products of glycolysis
2 ATP
2 Pyruvate
🔹Subpathway of glycolysis.
🔹Glucose to Lactic Acid.
🔹Happens if there is insufficient oxygen.
🔹Example during heavy exercises.
Anaerobic glycolysis
End product of anaerobic glycolysis
Lactic acid